41908-97-8

Basic information

• Product Name: 1-methyl-2-(4-methylphenyl)sulfonyl-benzene
• Synonyms: 1-methyl-2-(4-methylphenyl)sulfonyl-benzene
• CAS NO: 41908-97-8
• Molecular Formula: C₁₄H₁₄O₂S
• Molecular Weight: 246.3248
• Mol File: 41908-97-8.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 403.3°Cat760mmHg
• Flash Point: 238.8°C
• Appearance: /
• Density: 1.171g/cm³
• Vapor Pressure: 2.4E-06mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 1-methyl-2-(4-methylphenyl)sulfonyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-(4-methylphenyl)sulfonyl-benzene(41908-97-8)
• EPA Substance Registry System: 1-methyl-2-(4-methylphenyl)sulfonyl-benzene(41908-97-8)

Safety Data

• Hazardous Substances Data: 41908-97-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H14O2S/c1-11-7-9-13(10-8-11)17(15,16)14-6-4-3-5-12(14)2/h3-10H,1-2H3

Upstream product

• 108-88-3 toluene 
• 133-59-5 Toluene-2-sulfonyl chloride 
• 76339-61-2 Benzoesaeure-fluorsulfonsaeureanhydrid 
• 1858-86-2 Ethyl p-toluenesulfinate 
• 95-46-5 2-methylphenyl bromide 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-66-3 methoxybenzene 
• 104-15-4 toluene-4-sulfonic acid 
• 4124-41-8 p-toluenesulfonylanhydride 
• 16419-60-6 2-Methylphenylboronic acid 
• 33872-80-9 o-tolyl magnesium chloride 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 70-55-3 toluene-4-sulfonamide 
• 38542-71-1 N-methylpyridinium p-toluenesulfonate 

Relevant articles and documents

Metal-free sulfonylation of arenes with: N -fluorobenzenesulfonimide via cleavage of S-N bonds: expeditious synthesis of diarylsulfones

A novel metal-free sulfonylation of arenes with N-fluorobenzenesulfonimide (NFSI) toward the synthesis of diarylsulfones has been developed. The reaction represents a rare example of sulfonylation reaction using NFSI as an efficient sulfonyl donor and the first example of acid-mediated sulfonylation of unactivated arenes with NFSI via selective cleavage of S-N bonds. This protocol provides a concise approach for the construction of pharmaceutically and biologically important diarylsulfones. Applications in the functionalization of natural products (e.g., β-estradiol) and in the synthesis of a key intermediate to an inhibitor of farnesyl-protein transferase, as well as in the gram-scale synthesis of the EPAC2 antagonist, are demonstrated. This journal is

Catalyst-free arylation of sulfonamidesviavisible light-mediated deamination

A novel arylation of sulfonamides with boronic acids to afford numerous diaryl sulfonesviaa visible light-mediated N-S bond cleavage other than the typical transition-metal-catalyzed C(O)-N bond activation is described. This methodology, which represents the first catalyst-free protocol for the sulfonylation of boronic acids, is characterized by its simple reaction conditions, good functional group tolerance and high efficiency. Several successful examples for the late-stage functionalization of diverse sulfonamides indicate the high potential utility of this method in pharmaceutical science and organic synthesis.

Facile synthesis of diarylsulfones from arenes and 3CdSO4·xH2O via mechanochemistry

A variety of substituted diarylsulfones could be synthesized by simple arenes and 3CdSO4·xH2O in the presence of P2O5 under high-speed ball milling. It was suggest the aromatic sulfonation was performed by arene and in situ generated H2SO4, following-up by electrophilic substitution with another arene to give diarylsulfone.