41917-45-7

Basic information

• Product Name: 1,3-Benzodioxole-5-pentanoic acid
• Synonyms: 1,3-Benzodioxole-5-pentanoic acid;tetrahydropiperic acid
• CAS NO: 41917-45-7
• Molecular Formula: C12H14O4
• Molecular Weight: 222.23700
• Mol File: 41917-45-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1,3-Benzodioxole-5-pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzodioxole-5-pentanoic acid(41917-45-7)
• EPA Substance Registry System: 1,3-Benzodioxole-5-pentanoic acid(41917-45-7)

Safety Data

• Hazardous Substances Data: 41917-45-7(Hazardous Substances Data)

Upstream product

• 5285-18-7 5-(1,3-benzodioxol-5-yl)-2,4-pentadienoic acid 
• 33543-14-5 ethyl 5-(3,4-methylenedioxyphenyl)pentanoate 
• 6091-43-6 all-trans-5-(3,4-Methylendioxyphenyl)-2,4-pentadiensaeureethylester 
• 120-57-0 piperonal 
• 93399-76-9 3t-(1,3-Benzodioxol-5-yl)allylidenmalonsaeure 
• 190592-34-8 (E)-5-(benzo[d][1,3]dioxol-5-yl)pent-4-enoic acid 
• 94-59-7 1-allyl-3,4-methylenedioxybenzene 
• 122-59-8 2-phenoxyacetic acid 
• 136-72-1 piperic acid 
• 93399-42-9 3-(1,3-Benzodioxol-5-yl)propylmalonsaeure 

Downstream Products

• 23434-88-0 tetrahydropiperine 

Relevant articles and documents

Design, synthesis, trypanocidal activity, and studies on human albumin interaction of novel s-alkyl-1,2,4-triazoles

Chagas disease is a neglected tropical disease caused by the hemoflagellated parasite Trypanosoma cruzi (Kinetoplastida). The only available drug to treat chagasic patients in Brazil, the nitroheterocycle benznidazole, is effective solely during the acute phase of the infection. There is accordingly a need to develop new therapeutic tools for the treatment of Chagas disease. This work reports the synthesis, trypanocidal evaluation and human serum albumin (HSA) interactions of a novel series of 1,2,4-triazoles. The new derivatives were synthesized via microwave irradiation in good yields. Most compounds showed toxic effects against T. cruzi with low toxicity to host cells. Three S-alkylated-triazoles showed the best activity profile against amastigotes, with half maximal inhibitory concentration (IC50) values of 3.95 ± 1.41, 4.15 ± 0.92 and 3.61 ± 0.65 μmol L-1, respectively. The interaction between HSA and 3-[(1E,3E)-4-(1,3-benzodioxol-5-yl)buta-1,3-dien-1-yl]-5-(butylthio)-4-cyclohexyl-4,5-dihydro-1H-1,2,4-triazole was investigated using multiple spectroscopic techniques and molecular docking, revealing that serum albumin is a potential endogenous carrier to this compound in the human bloodstream.

New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2

Group VIA calcium-independent phospholipase A2 (GVIA iPLA 2) has recently emerged as an important pharmaceutical target. Selective and potent GVIA iPLA2 inhibitors can be used to study its role in various neurological diso

Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: Chemical and biological studies

We herein describe the synthesis and characterization of nine new 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine. We evaluate their toxic effects against the different evolutive forms of Trypanosoma cruzi, and the host cell (murine macrophages). The results obtained show that mesoionic hydrochloride MI possesses the best activity profile. Compound MI may be a prototype for use in the development of a new chemotherapeutic agent with high efficiency, which may be employed in the treatment of Chagas' disease.