4195-21-5

Basic information

• Product Name: 3-(4-morpholinyl)-2-benzofuran-1(3H)-one
• Synonyms: 3-(4-morpholinyl)-2-benzofuran-1(3H)-one;3-Morpholin-4-yl-3H-isobenzofuran-1-one
• CAS NO: 4195-21-5
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.23652
• Mol File: 4195-21-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 171 °C (decomp)
• Boiling Point: 145 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.302±0.06 g/cm3(Predicted)
• PKA: 3.32±0.20(Predicted)
• CAS DataBase Reference: 3-(4-morpholinyl)-2-benzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-morpholinyl)-2-benzofuran-1(3H)-one(4195-21-5)
• EPA Substance Registry System: 3-(4-morpholinyl)-2-benzofuran-1(3H)-one(4195-21-5)

Safety Data

• Hazardous Substances Data: 4195-21-5(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 119-67-5 o-carboxybenzaldehyde 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 6940-49-4 3-Bromophthalide 
• 61296-43-3 3-Iodo-1(3H)-isobenzofuranone 
• 6295-21-2 3-chloro-1(3H)-isobenzofuranone 
• 87-41-2 2-benzofuran-1(3H)-one 

Downstream Products

• 110-91-8 morpholine 
• 119-67-5 o-carboxybenzaldehyde 

Relevant articles and documents

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The investigation of nucleophilic reactions of 3 -bromo/chloro phthalide with amines

The reaction of 3-bromo/chloro phthalide 1a/b with secondary amines in polar solvents gives the corresponding amides of 2-formylbenzoic acid, while in nonpolar solvents gives 3-aminophthalides. The reaction of 1a/b with aromatic primary amines gives 3-arylaminophthalides, while with aliphatic primary amines 3-hydroxyphthalimidines are obtained.

SYNTHESIS OF AMINO AND PHOSPHORUS DERIVATIVES FROM 3-BROMOPHTHALIDE

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