419539-34-7

Basic information

• Product Name: C₂₁H₁₃FN₂O₃
• CAS NO: 419539-34-7
• Molecular Weight: 360.344
• Mol File: 419539-34-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₃FN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₃FN₂O₃(419539-34-7)
• EPA Substance Registry System: C₂₁H₁₃FN₂O₃(419539-34-7)

Safety Data

• Hazardous Substances Data: 419539-34-7(Hazardous Substances Data)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 40101-51-7 3-(1,3-dioxoisoindolin-2-yl)benzoic acid 

Relevant articles and documents

Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS

This Letter describes the discovery and SAR of three novel series of mGluR5 non-competitive antagonists/negative allosteric modulators (NAMs) not based on manipulation of an MPEP/MTEP chemotype identified by a functional HTS approach. This work demonstrates fundamentally new mGluR5 NAM chemotypes with submicromolar potencies, and further examples of a mode of pharmacology 'switch' to provide PAMs with a non-MPEP scaffold.