41965-71-3

Basic information

• Product Name: 2-Propenoyl chloride, 2-broMo-
• Synonyms: 2-Propenoyl chloride, 2-broMo-
• CAS NO: 41965-71-3
• Molecular Formula: C₃H₂BrClO
• Molecular Weight: 169.40438
• Mol File: 41965-71-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenoyl chloride, 2-broMo-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoyl chloride, 2-broMo-(41965-71-3)
• EPA Substance Registry System: 2-Propenoyl chloride, 2-broMo-(41965-71-3)

Safety Data

• Hazardous Substances Data: 41965-71-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-2-Propenoyl Chloride is a highly reactive chemical compound, often used for various chemical synthesis. Chemically, it falls into the classification of Acid Halides or, more specifically, Bromo Acid Chlorides. Its properties, including volatility and extreme reactivity with water, make it a useful chemical in industrial applications, but also imply that it must be handled carefully. It is considered harmful if swallowed or inhaled and may cause severe burns and eye damage. It is generally stored and transported in effective containers under controlled conditions.

Upstream product

• 10443-65-9 2-bromo-2-propenoic acid 

Downstream Products

• 63046-45-7 2-[(2-Bromo-acryloyl)-(2-ethyl-6-methyl-phenyl)-amino]-thiopropionic acid S-methyl ester 
• 39773-12-1 N-phenyl-2-bromo-acrylic acid amide 
• 287734-05-8 4-(2-bromo-acryloylamino)-1-methyl-1H-pyrrole-2-carboxylic acid phenylamide 
• 35601-00-4 2-Bromo-N-(4-fluoro-phenyl)-acrylamide 
• 35600-90-9 2-Bromo-N-(4-methylphenyl)-2-propenamide 
• 35600-92-1 2-Bromo-N-(4-chlorophenyl)-2-propenamide 
• 63407-43-2 2-Bromo-N-(4-methoxyphenyl)-2-propenamide 

Relevant articles and documents

Anionic Bisoxazoline Ligands Enable Copper-Catalyzed Asymmetric Radical Azidation of Acrylamides

Asymmetric radical azidation for the synthesis of chiral alkylazides remains a tremendous challenge in organic synthesis. We report here an unprecedented highly enantioselective radical azidation of acrylamides catalyzed by 1 mol % of a copper catalyst. The substrates were converted to the corresponding alkylazides in high yield with good-to-excellent enantioselectivity. Notably, employing an anionic cyano-bisoxazoline (CN-Box) ligand is crucial to generate a monomeric CuII azide species, rather than a dimeric CuII azide intermediate, for this highly enantioselective radical azidation.

Cobalt(III)-Catalyzed Directed C-H Allylation

The cobalt(III)-catalyzed allylation was developed for amide-directed C-H activation of arenes, heteroarenes, and olefins. A variety of allyl sources can be employed to introduce this useful functional group.

A novel synthesis of (-)-huperzine A via tandem intramolecular aza-Prins cyclization-cyclobutane fragmentation

The acetylcholinesterase inhibitor (-)-huperzine A was synthesized from (S)-4-hydroxycyclohex-2-enone in 17 steps by a route that involved two cyclobutane fragmentations. The first of these employed a retro-aldol cleavage to generate the α-pyridone ring o