41994-50-7Relevant articles and documents
Tetracyclic pyrimidinone compound, preparation method, composition and application thereof
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, (2021/03/31)
A tetracyclic pyrimidinone compound represented by a formula (I) or a pharmaceutically acceptable salt thereof has a structure represented by a formula (I), is a brand new Lp-PLA2 inhibitor, and can be used for treating neurodegenerative related diseases such as Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), or cardiovascular diseases including atherosclerosis and thelike.
COMPOUNDS THAT MODULATE ENDOTHELIN ACTIVITY
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, (2008/06/13)
Compounds of formula (I) and pharmaceutical compositions containing the compounds of formula (I): STR1 are provided. In formula (I): Ar is a substituted or unsubstituted aromatic or heterocyclic group; R is H or a substituted or unsubstituted straight or branched chain, cyclic or mixture of straight branched and cyclic alkyl, alkenyl, or alkynyl group having from 1-20 carbon atom; A is a functional group that bears a polar moiety; R 1 is R, R--C=0, R substituted with one or more heteroatoms, a substituted or unsubstituted aryl group, or is aryl-(CH 2) n ; R 2 is (CH 2) n, CHR, C(R) 2, COO, OCO, NHCO, CONH, SO, SO 2 or NR; R 3 and R 4, which are the same or different or each may be absent, and are =O, H, O-aryl, OR, O-alkyl or alkyl, aryl, SR, S-aryl, NHR, NH-aryl, NR, or are other heteroaromatic groups; R 5 is H, OH or R; E and F, which are the same or are different, are either N or (CH 2) p ; p is an integer or 0 between 0 and 5; m and n are integers or 0 between 0 and 10; T is O, S, NCOR or NR; U and V, which may be the same or different, are (CH. sub.2) n; W is CO, (CH 2)n, (CH 2) n--CHR or CHR--(CH 2) n ; X and Y, which may be the same or different, are H, alkyl or aryl or X and Y form a saturated or unsaturated homocyclic or heterocyclic ring contain 3-15 members; and Z is H, SR, NHR or N(R) 2.
