420135-49-5Relevant articles and documents
Diastereoselective synthesis of cyclic β2,3-amino acids utilizing 4-substituted-1,3-oxazinan-6-ones
Sleebs, Brad E.,Nguyen, Nghi H.,Hughes, Andrew B.
, p. 6275 - 6284 (2013/07/27)
The 4-substituted-1,3-oxazinan-6-one scaffold is a versatile synthon enabling access to a diverse array of β-amino acid derivatives. In this study, the synthetic utility of the 1,3-oxazinan-6-one is expanded to include the diastereoselective synthesis of
CYCLIC NATRIURETIC PEPTIDE CONSTRUCTS
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Page/Page column 52-53, (2008/06/13)
Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R', Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti hypertensive, cardiovascular, renal or endocrine effects are desired.
Synthesis and evaluation of enantiomeric purity of protected α-amino and peptide aldehydes
Mindt, Thomas,Michel, Urs,Dick
, p. 1960 - 1968 (2007/10/03)
The synthesis of enantiomerically pure Ac-Tyr-Val-Ala-Asp(O'Bu)-H dimethyl acetal ((S)-1) is reported, a protected tetrapeptide C-terminal aldehyde belonging to a class of potent, reversible inhibitors of cysteine proteases (e.g., interleukin-1β-convertin
