42019-08-9

Basic information

• Product Name: FENOFIBRIC ACID ETHYL ESTER
• Synonyms: 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-propanoicaciethylester;2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid ethyl ester;2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic acid ethyl ester;Ethyl 2-(4-(4-Chlorobenzoyl)Phenoxy)-2-Methylpropanoate;Fenofibrate iMpurity E;FENOFIBRIC ACID ETHYL ESTER;Fenofibrate impurity E (EP);Fenofibric acid Impurity C
• CAS NO: 42019-08-9
• Molecular Formula: C₁₉H₁₉ClO₄
• Molecular Weight: 346.8
• Product Categories: pharmacetical;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 42019-08-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 79 °C
• Boiling Point: 463.1°Cat760mmHg
• Flash Point: 167.9°C
• Appearance: /
• Density: 1.197g/cm³
• Vapor Pressure: 9.36E-09mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: FENOFIBRIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: FENOFIBRIC ACID ETHYL ESTER(42019-08-9)
• EPA Substance Registry System: FENOFIBRIC ACID ETHYL ESTER(42019-08-9)

Safety Data

• Hazardous Substances Data: 42019-08-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H19ClO4/c1-4-23-18(22)19(2,3)24-16-11-7-14(8-12-16)17(21)13-5-9-15(20)10-6-13/h5-12H,4H2,1-3H3

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 42019-78-3 4-chloro-4'-hydroxybenzophenone 

Downstream Products

• 42017-89-0 fenofibric acid 

Relevant articles and documents

Synthesis technology of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl propionic acid

The invention relates to a synthesis technology of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl propionic acid. The invention aims to solve the technical problems that a conventional fenofibric acid synthesis method has violent reaction in the preparation process and the purity of prepared products is low. The technical scheme comprises that the synthesis technology of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl propionic acid includes the steps: under an alkaline condition, carrying out a substitution reaction of (4-chloro-phenyl)-(4-hydroxy-phenyl)-methanone with 2-ethyl bromoisobutyrate in an organic solvent to obtain 2-[4-(4-chloro-benzoyl)-phenoxy]-2-methyl-ethyl propionate; hydrolyzing the obtained product in an organic solvent under an alkaline condition, to obtain a 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl propionic acid crude product; and carrying out recrystallization of the compound crude product obtained from hydrolysis for two times to obtain the target product.