42022-03-7 Usage
Description
N-NITROSO-D-PROLINE is a nitrosoamino acid with oncogenic activity, which means it has the potential to cause cancer. It is characterized by its ability to induce tumors in living organisms. The lethal dose 50 (LD50) of a single intraperitoneal (ip) dose given to Swiss-Webster mice is 203 +/22 mg/kg, indicating its toxicity at high doses.
Uses
N-NITROSO-D-PROLINE is used as a research chemical for studying the mechanisms of carcinogenesis and the effects of nitrosamines on biological systems. Its oncogenic properties make it a valuable tool for understanding the development of cancer and the factors that contribute to its progression.
Used in Pharmaceutical Research:
N-NITROSO-D-PROLINE is used as a pharmaceutical research compound for investigating the role of nitrosoamino acids in the etiology of cancer and for developing potential therapeutic agents to counteract their effects.
Used in Toxicological Studies:
N-NITROSO-D-PROLINE is used as a toxicological agent in studies aimed at understanding the dose-response relationship and the potential health risks associated with exposure to nitrosamines.
Check Digit Verification of cas no
The CAS Registry Mumber 42022-03-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,0,2 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 42022-03:
(7*4)+(6*2)+(5*0)+(4*2)+(3*2)+(2*0)+(1*3)=57
57 % 10 = 7
So 42022-03-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H8N2O3/c8-5(9)4-2-1-3-7(4)6-10/h4H,1-3H2,(H,8,9)/t4-/m1/s1
42022-03-7Relevant articles and documents
NITROSATION REAGENTS AND METHODS
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Paragraph 00158; 00182; 00183; 00186-00189; 00222-00225; ..., (2022/02/06)
Provided are compounds that can find use as nitrosation reagents. Provided are nitrosation methods that include reacting a substrate with one of the provided nitrosation reagents and thereby generating a nitrosation product. Provided are kits including a nitrosation reagent. Provided are compositions wherein the nitrosation reagent is enriched in the 15N isotope.
Big ring indole used as MCL-1 inhibitor
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Paragraph 1702; 1705-1707, (2020/03/12)
The invention provides a compound represented by a formula (I) and a pharmaceutical salt and solvate thereof. In the formula (I), the definitions of R, R1a, R1b, R1h, L1, L2, and L3 are shown in the description. The invention also provides a compound represented by the formula (I), and the compound can be used to treat disease or disorder related with MCL-1 inhibition, such as cancers.
