42036-79-3

Basic information

• Product Name: Phosphonium salt of [1-BROMOOCTADECANE]
• Synonyms: Phosphonium salt of [1-BROMOOCTADECANE]
• CAS NO: 42036-79-3
• Molecular Weight: 595.687
• Mol File: 42036-79-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Phosphonium salt of [1-BROMOOCTADECANE](CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonium salt of [1-BROMOOCTADECANE](42036-79-3)
• EPA Substance Registry System: Phosphonium salt of [1-BROMOOCTADECANE](42036-79-3)

Safety Data

• Hazardous Substances Data: 42036-79-3(Hazardous Substances Data)

Upstream product

• 112-89-0 1-Bromooctadecane 
• 603-35-0 triphenylphosphine 

Downstream Products

• 104410-91-5 7(Z),11(Z)-nonacosadiene 
• 57243-06-8 Octadecyltriphenylphosphorane 
• 63623-49-4 (E)-7-pentacosene 
• 63623-49-4 (Z)-7-pentacosene 
• 443921-66-2 (E)-(R)-2-Benzyloxy-docos-4-en-1-ol 
• 593-50-0 melissyl alcohol 
• 506-50-3 melissic acid 
• 629-83-4 methyl 1-triacontanoate 
• 1191301-89-9 C₂₇H₄₆O₂ 

Relevant articles and documents

Ortho -Substituted lipidated Brartemicin derivative shows promising Mincle-mediated adjuvant activity

The macrophage inducible C-type lectin (Mincle) is a pathogen recognition receptor (PRR) that is a promising target for the development of Th1-polarising vaccine adjuvants. We recently reported on the synthesis and evaluation of lipidated Brartemicin analogues that showed Mincle agonist activity, with our lead agonist exhibiting potent Th1 adjuvant activity that was greater than that of trehalose dibehenate (TDB). Herein, we report on the efficient synthesis and subsequent biological evaluation of additional lipidated Brartemicin analogues that were designed to determine the structural requirements for optimal Mincle signalling. While all the Brartemicin analogues retained their ability to signal through Mincle and induce a functional response, the o-substituted and m,m-disubstituted derivatives (5a and 5d, respectively) induced a potent inflammatory response when using cells of both murine and human origin, with this response being the greatest observed thus far. As the inflammatory response elicited by 5a was slightly better than that induced by 5d, our findings point to o-substituted Brartemicin analogues as the preferred scaffold for further adjuvant development.

A method for preparing high-purity triacontanol (by machine translation)

A method for utilizing organic synthesis for preparing high-purity triacontanol method, which belongs to the field of organic synthesis. To provide a reliable source of raw materials, the process is simple, the yield is high purity, easy large-scale production of the method of preparing triacontanol. In order to 1, 12 - dodecanediol as raw material preparation 12 - tert butyl dimethyl siloxy lauryl alcohol, TEMPO oxidation for 12 - tert butyl dimethyl siloxy lauric aldehyde, preparation octadecyl triphenyl brominated [...], tertiary butyl dimethoxy melissane silane - 12 - ene, preparation triacontanol. The raw materials are all industrial chemistry, the process is simple, high chemical yield, high purity of the product, it is easy to industrialization and more environmentally friendly. (by machine translation)

Ionic liquids: Structuration agents in a fluorinated matrix

The use of ionic liquids as functional building blocks based on pyridinium, imidazolium and phosphonium cations to achieve materials combining a structuration at nanoscale with the dramatic mechanical properties of the resulting ionomers has been successf