42060-32-2

Basic information

• Product Name: N-benzyl-2-nitrobenzenesulfonamide
• Synonyms: N-benzyl-2-nitrobenzenesulfonamide
• CAS NO: 42060-32-2
• Molecular Formula: C₁₃H₁₂N₂O₄S
• Molecular Weight: 292.31038
• Mol File: 42060-32-2.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-benzyl-2-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-nitrobenzenesulfonamide(42060-32-2)
• EPA Substance Registry System: N-benzyl-2-nitrobenzenesulfonamide(42060-32-2)

Safety Data

• Hazardous Substances Data: 42060-32-2(Hazardous Substances Data)

Usage

General Description

N-benzyl-2-nitrobenzenesulfonamide is a chemical compound with the molecular formula C13H12N2O4S. It is commonly used as a reagent in organic synthesis and pharmaceutical research. Its structure consists of a benzene ring substituted with a nitro group and a sulfonamide group, as well as a benzyl group attached to the nitrogen atom. N-benzyl-2-nitrobenzenesulfonamide has been studied for its potential as an antitumor and antiparasitic agent. Its properties and reactivity make it a valuable building block in the synthesis of various biologically active compounds. Additionally, it is also used as a research tool in the study of enzyme inhibition and protein binding.

Upstream product

• 141381-72-8 1H-benzo[d][1,2,3]triazol-1-yl 2-nitrobenzenesulfonate 
• 100-46-9 benzylamine 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 245364-47-0 N-Boc-N-benzyl-o-nitrobenzenesulfonamide 
• 5455-59-4 2-Nitrobenzenesulfonamide 
• 100-51-6 benzyl alcohol 
• 198572-71-3 N-(tert-butoxycarbonyl)-2-nitrobenzenesulfonamide 
• 103-82-2 phenylacetic acid 
• 1441409-96-6 (E)-ethyl 2-cyano-2-(2-nitrophenylsulfonyloxyimino)acetate 
• 62-53-3 aniline 

Downstream Products

• 42060-39-9 N-methyl-N-benzyl-o-nitrobenzenesulfonamide 
• 235089-83-5 N-benzyl-2-nitro-N-(1-phenethyl-allyl)-benzenesulfonamide 
• 483341-86-2 (1S,4S,6R)-4,6-bis[(N-benzyl)-o-nitrobenzenesulfon-amino]-cyclohex-2-enol 
• 483341-81-7 (1R,4R,6S)-4,6-bis[(N-benzyl)-o-nitrobenzenesulfon-amino]-cyclohex-2-enol 
• 100-46-9 benzylamine 
• 349397-37-1 N-benzyl-N-isopropyl-2-nitrobenzenesulfonamide 
• 879999-17-4 2,3-isopropylidenedioxy-5-(N-benzylamino)-1-uracyl-β-D-ribofuranose 
• 879999-14-1 Acetic acid (2R,3R,4R,5S)-4,5-diacetoxy-2-{[benzyl-(2-nitro-benzenesulfonyl)-amino]-methyl}-tetrahydro-furan-3-yl ester 

Relevant articles and documents

One-pot synthesis ofN-substituted benzannulated triazolesviastable arene diazonium salts

A mild and effective one-pot synthesis of 1,2,3-benzotriazin-4(3H)-ones and benzothiatriazine-1,1(2H)-dioxide analogues has been developed. The method involves the diazotisation and subsequent cyclisation of 2-aminobenzamides and 2-aminobenzenesulfonamidesviastable diazonium salts, prepared using a polymer-supported nitrite reagent andp-tosic acid. The transformation was compatible with a wide range of aryl functional groups and amide/sulfonamide-substituents and was used for the synthesis of pharmaceutically important targets. The synthetic utility of the one-pot diazotisaton-cyclisation process was further demonstrated with the preparation of an α-amino acid containing 1,2,3-benzotriazin-4(3H)-one.

Direct Synthesis of Allyl Amines with 2-Nitrosulfonamide Derivatives via the Tsuji-Trost Reaction

The Tsuji-Trost Reaction is a palladium-catalysed allylation of nucleophiles that consists in the reaction of a nitrogen, carbon or oxygen-based nucleophiles with an allylic substrate bearing a leaving group. Here we present the use of 2-nitrosulfonamide derivatives as nucleophile, which are reactive under mild conditions. 2-nitrosulfonyl groups are well-known dual protective activator groups easy to introduce in any type of amine substrates. The resulting 2-nitrosulfonamide derivatives are ideal substrates for the Tsuji-Trost reaction to afford a convenient and flexible access to primary and dissymmetric secondary allyl amines. The optimised procedure is flexible (for solvent, temperature, functional groups) and has been applied with good to excellent yield to access to a wide range of allyl amine derivatives.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE

Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.