420782-25-8

Basic information

• Product Name: ethyl 3-phenyl-4,7-dioxo-4,7-dihydrobenzo[b]thiophene-2-carboxylate
• CAS NO: 420782-25-8
• Molecular Weight: 312.346
• Mol File: 420782-25-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-phenyl-4,7-dioxo-4,7-dihydrobenzo[b]thiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-phenyl-4,7-dioxo-4,7-dihydrobenzo[b]thiophene-2-carboxylate(420782-25-8)
• EPA Substance Registry System: ethyl 3-phenyl-4,7-dioxo-4,7-dihydrobenzo[b]thiophene-2-carboxylate(420782-25-8)

Safety Data

• Hazardous Substances Data: 420782-25-8(Hazardous Substances Data)

Upstream product

• 2050-37-5 2,5-dihydroxybenzophenone 
• 106-51-4 p-benzoquinone 
• 100-52-7 benzaldehyde 
• 36041-39-1 2-benzoyl-1,4-benzoquinone 

Downstream Products

• 859218-52-3 ethyl 5-hydroxy-4,7-dioxo-3-phenyl-4,7-dihydrobenzo[b]thiophene-2-carboxylate 

Relevant articles and documents

An improved method for the preparation of 4,7-Dioxo-4,7-dihydrobenzo[b]thiophene-2-carboxylates from 2-acyl-1,4-benzoquinones and mercaptoacetates

4,7-Dioxo-4,7-dihydrobenzo[b]thiophene-2-carboxylates (4) have been synthesized in a one-pot procedure from 2-acyl-1,4-benzoquinones (1) and mercaptoacetates (2) by using 1-trimethylsilylimidazole as a protective reagent as well as a base. Thus, reaction of 1 with 2 in THF at room temperature was followed by treatment with excess of 1-trimethylsilylimidazole at 80°C. Then the cooled mixture was hydrolyzed with hydrochloric acid and oxidized with cerium(IV) ammonium nitrate (CAN) to give the expected thiophenequinone derivatives (4). 4,9-Dioxo-4,9-dihydronaphtho[2,3-b]thiophene-2-carboxylates (7) were similarly prepared from 2-acyl-1,4-naphthoquinones (5) and mercaptoacetates, in general, by omitting the CAN oxidation procedure.