4208-67-7 Usage
Description
[[5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid is a complex nucleotide analog compound with a unique structure that consists of pyrimidin-1-yl, oxolan-2-yl, methoxy, hydroxy, phosphoryl, and oxyphosphonic acid moieties. It is recognized for its potent inhibitory effects on viral RNA polymerases, making it a promising candidate for antiviral drug development.
Uses
Used in Pharmaceutical Industry:
[[5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid is used as an antiviral agent for its ability to inhibit viral RNA polymerases, potentially interfering with the replication of viral genetic material and the synthesis of viral RNA. This application is particularly relevant in the development of treatments for a wide range of viral infections.
Used in Research and Development:
In the field of virology and molecular biology, [[5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxyphosphonic acid serves as a valuable research tool to study the mechanisms of viral replication and the development of antiviral therapies. Further research and testing are necessary to fully comprehend its mechanism of action and therapeutic potential, which could lead to the creation of novel antiviral drugs and treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 4208-67-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,0 and 8 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4208-67:
(6*4)+(5*2)+(4*0)+(3*8)+(2*6)+(1*7)=77
77 % 10 = 7
So 4208-67-7 is a valid CAS Registry Number.
4208-67-7Relevant articles and documents
Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Vanheusden, Veerle,Van Rompaey, Philippe,Munier-Lehmann, Helene,Pochet, Sylvie,Herdewijn, Piet,Van Calenbergh, Serge
, p. 3045 - 3048 (2003)
The affinity of a series of 2′, 3′- and 5-modified thymidine analogues for Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) was evaluated. The affinities of several non-phosphorylated analogues are in the same order of magnitude as those of their phosphorylated congeners. In view of drug delivery problems associated with phosphorylated compounds, these 'free' nucleosides seem more promising leads in the search of TMPKmt inhibitors as novel anti-tuberculosis agents.
Nucleoside-Triphosphatase Activity of an ATP-Dependent Enzyme, N-Methylhydantoin Amidohydrolase
Ogawa, Jun,Nirdnoy, Warawadee,Yamada, Hideaki,Shimizu, Sakayu
, p. 1737 - 1739 (2007/10/02)
N-Methylhydantoin amidohydrolase, which catalyzes ATP-dependent hydrolysis of N-methylhydantoin to N-carbamoylsarcosine, was found to hydrolyze several nucleoside triphosphates to nucleoside diphosphates not only in the presence but also in the absence of amide substrates.Amide substrates, such as N-methylhydantoin and dihydrouracil, seem to be absolutely necessary for hydrolysis of ATP and dATP.However, N-methylhydantoin inhibited the hydrolysis of nucleoside triphosphates other than ATP and dATP.The kinetic data suggest that the presence of an amide substrate changes the affinity of the enzyme toward nucleoside triphosphates.
