421-85-2 Usage
Description
Trifluoromethanesulfonamide, also known as triflyl amide or triflate amide, is a chemical compound with the formula CF3SO2NH2. It is a white to off-white solid and is commonly used as an intermediate in synthetic chemistry due to its versatile reactivity and stability.
Uses
Used in Synthetic Chemistry:
Trifluoromethanesulfonamide is used as an intermediate in synthetic chemistry for various applications, including the preparation of specific inhibitors of mammalian secreted phospholipases A2. These inhibitors play a crucial role in regulating the activity of enzymes involved in the production of inflammatory mediators, which can be beneficial in the treatment of various inflammatory diseases.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, trifluoromethanesulfonamide is involved in the synthesis of ecicosanoids, which are a group of biologically active compounds derived from polyunsaturated fatty acids. These compounds have diverse physiological functions, including the regulation of inflammation, blood clotting, and immune responses. The development of drugs targeting ecicosanoid pathways can potentially lead to novel therapeutic approaches for various diseases.
Used in Research and Development:
Trifluoromethanesulfonamide is also utilized in research and development for the design and synthesis of new chemical entities with potential applications in various fields, such as pharmaceuticals, materials science, and agrochemicals. Its unique chemical properties make it a valuable building block for the creation of novel molecules with specific biological activities or material properties.
Check Digit Verification of cas no
The CAS Registry Mumber 421-85-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,2 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 421-85:
(5*4)+(4*2)+(3*1)+(2*8)+(1*5)=52
52 % 10 = 2
So 421-85-2 is a valid CAS Registry Number.
InChI:InChI=1/CH2F3NO2S/c2-1(3,4)8(5,6)7/h(H2,5,6,7)
421-85-2Relevant articles and documents
Reaction of N,N′-Methylenebis(trifluoromethanesulfonamide) with Styrene under Oxidative Conditions
Moskalik, M. Yu.,Astakhova,Ganin,Shainyan
, p. 734 - 736 (2019/07/17)
The reaction of N,N′-methylenebis(trifluoromethanesulfonamide) with styrene in the oxidative system t-BuOCl/NaI affords triflamide, 2-iodo-1-phenylethanol, N,N′-bis(trifluoromethanesulfonyl)urea, and the product of styrene bistriflamidation. The mechanism
PERFLUOROALKYL SULFONAMIDE AND METHOD FOR PRODUCING THE SAME
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Paragraph 0070-0074, (2018/06/05)
PROBLEM TO BE SOLVED: To simply provide high-purity perfluoroalkyl sulfonamide by efficiently reducing bis(perfluoroalkyl sulfone)imide, an impurity to be generated in a production process. SOLUTION: High-purity perfluoroalkyl sulfonamide is obtained by reducing bis(perfluoroalkyl sulfone)imide by washing perfluoroalkyl sulfonamide expressed by the following formula (1), which contains the bis(perfluoroalkyl sulfone)imide, with a chlorinated solvent: RfSO2 NH2, provided that, in the formula (1), Rf is a straight or branched 1-4C perfluoroalkyl group. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
Reaction of N-sulfinyltrifluoromethanesulfonamide with triphenylphosphine and triphenylphosphine oxide
Tolstikova,Bel'Skikh,Shainyan
scheme or table, p. 1189 - 1192 (2011/01/10)
The reaction of N-sulfinyltrifluoromethanesulfonamide with triphenylphosphine and triphenylphosphine oxide or of trifluoromethanesulfonamide with dichloro(triphenyl)phosphorane leads to trifluoro-N-(triphenyl-λ5-phosphanylidene)methanesulfonamide, which is hydrolyzed to trifluoromethanesulfonamide and triphenylphosphine oxide via the intermediate trifluoro-N-[hydroxy(triphenyl)phosphoranyl] methanesulfonamide.
