42110-76-9

Basic information

• Product Name: 5-chloro-1-Methyl-1H-pyrazole
• Synonyms: 5-chloro-1-Methyl-1H-pyrazole
• CAS NO: 42110-76-9
• Molecular Formula: C4H5ClN2
• Molecular Weight: 116.5489
• Mol File: 42110-76-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 134 °C
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 1.01±0.10(Predicted)
• CAS DataBase Reference: 5-chloro-1-Methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-1-Methyl-1H-pyrazole(42110-76-9)
• EPA Substance Registry System: 5-chloro-1-Methyl-1H-pyrazole(42110-76-9)

Safety Data

• Hazardous Substances Data: 42110-76-9(Hazardous Substances Data)

Upstream product

• 29184-68-7 2-methylpyrazole 1-oxide 
• 930-36-9 1-methyl-1H-pyrazole 

Relevant articles and documents

Method for synthesizing 5-difluoromethoxy-3-trifluoromethyl-1-methyl pyrazole

The invention relates to the field of organic synthesis, in particular to a method for synthesizing 5-difluoromethoxy-3-trifluoromethyl-1-methyl pyrazole. The method includes the following steps of: 1-methyl pyrazole reacts with a halogenating agent under the action of a metal reagent to generate 5-halogenation-1-methyl pyrazole, wherein the 5-halogenation-1-methyl pyrazole reacts with difluoro methyl alcohol under the catalyzing of alkali to obtain 1-methyl-5-difluoromethoxazole; the 1-methyl-5-difluoromethoxazole reacts with a trifluoromethylating reagent under the action of visible light catalysis and a photocatalyst to obtain 5-difluoromethoxy-3-trifluoromethyl-1-methyl pyrazole. The method has the advantages that by redesigning the route, the method can obtain the 5-difluoromethoxy-3-trifluoromethyl-1-methyl pyrazole with high yield and high selectivity by using raw materials which are cheaper and easier to obtain.

Synthesis of 2-Alkylpyrazole-1-oxides: A Facile Access to 1-Alkyl-5-halopyrazoles

Selective N-alkylation of 1-hydroxypyrazole 1 into the corresponding 2-alkyl-pyrazole-1-oxides 2a-f has been achieved by treatment with alkyl bromides in the absence of base. Subsequent deoxygenation/halogenation into 1-alkyl-5-halopyrazoles 3a-d and 4a-d using phosphorus oxyhalides is described.