42116-43-8

Basic information

• Product Name: 1-(TERT-BUTOXYCARBONYL)-2-PHENYLHYDRAZINE
• Synonyms: 1-(TERT-BUTOXYCARBONYL)-2-PHENYLHYDRAZINE;Hydrazinecarboxylic acid, 2-phenyl-, 1,1-dimethylethyl ester (9CI);1-Boc-2-phenylhydrazine;2-Phenylhydrazinecarboxylic acid 1,1-dimethylethyl ester;3-Phenylcarbazic acid tert-butyl ester;N-Boc-N′-phenylhydrazine;tert-Butyl-2-phenylhydrazinecarboxylate;1-Boc-2-phenylhydrazine 97%
• CAS NO: 42116-43-8
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.25694
• Product Categories: N-BOC
• Mol File: 42116-43-8.mol
• Article Data: 27

Chemical Properties

• Melting Point: 90-94°C
• Appearance: /
• CAS DataBase Reference: 1-(TERT-BUTOXYCARBONYL)-2-PHENYLHYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TERT-BUTOXYCARBONYL)-2-PHENYLHYDRAZINE(42116-43-8)
• EPA Substance Registry System: 1-(TERT-BUTOXYCARBONYL)-2-PHENYLHYDRAZINE(42116-43-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 42116-43-8(Hazardous Substances Data)

Usage

Appearance

White to beige crystalline powder

Usage

Reagent for the synthesis of various organic compounds

Application

Preparation of pharmaceuticals, agrochemicals, and other fine chemicals

Stability

Highly stable compound

Toxicity

Low toxicity

Role

Versatile building block in organic chemistry

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 100-63-0 phenylhydrazine 
• 57022-34-1 tert-butyl cyanoformate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 62-53-3 aniline 
• 462100-44-3 oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester 
• 68014-21-1 triphenyl(t-butoxycarbonylimino)phosphorane 
• 408346-61-2 2-(N-tert-butoxycarbonylimino)malonic acid diethyl ester 
• 35454-04-7 oxalamic Acid Tert-butyl Ester 
• 50624-94-7 oxalic acid tert-butyl ester ethyl ester 
• 34619-03-9 tert-butyldicarbonate 
• 59-88-1 phenylhydrazine hydrochloride 
• 870-46-2 t-butoxycarbonylhydrazine 
• 17763-67-6 Phenyl triflate 

Downstream Products

• 60295-43-4 N-benzoyl-N-phenyl-N'-tert-butoxycarbonyl hydrazine 
• 65578-58-7 di-tert-butyl 1-phenylhydrazine-1,2-dicarboxylate 
• 92491-22-0 tert-butyl 2-phenyldiazene-1-carboxylate 
• 196513-39-0 N-(tert-Butoxycarbonyl)-N'-((2S)-N-chloroacetylprolyl)-N'-phenylhydrazine 
• 312934-59-1 2,2-Bis(t-butyloxycarbonyl)-1-phenylhydrazine 
• 312934-60-4 1,1,2-tris(tert-butoxycarbonyl)-2-phenylhydrazine 
• 166974-95-4 3-oxo-2-phenylpyrazolidine-1-carboxylic acid tert-butyl ester 
• 166974-84-1 3-oxo-2-phenyltetrahydropyridazine-1-carboxylic acid tert-butyl ester 
• 497155-24-5 (N'-tert-butoxycarbonyl-N-phenyl-hydrazino)-(4-methoxy-phenyl)-acetic acid 
• 521286-20-4 N'-phenyl-N-(4-nitro-phenyl)hydrazinecarboxylic acid tert-butyl ester 
• 17223-84-6 tert-butyl 2,2-diphenylhydrazinecarboxylate 

Relevant articles and documents

Hydrogen peroxide based oxidation of hydrazines using HBr catalyst

Azo compounds (RN = NR′) are an important class of organic molecules that find wide application in organic synthesis. Herein, we report an efficient, practical and metal-free oxidation of hydrazines (RNH-NHR’) to azo compounds using 5 mol% HBr and hydrogen peroxide as terminal oxidant. This new method has been demonstrated by 40 examples with excellent yields. In addition, we showcased two examples of the one-pot sequential reactions involving our hydrazine oxidation/hydrolysis/Heck reaction or Cu-catalyzed N-arylation with aryl boronic acid. The distinct advantages of this protocol include metal-free catalysis, waste prevention, and easy operation.

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technology includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes.