42134-72-5

Basic information

• Product Name: 2,3-bis(4-(trifluoromethyl)phenyl)propanenitrile
• CAS NO: 42134-72-5
• Molecular Weight: 343.271
• Mol File: 42134-72-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,3-bis(4-(trifluoromethyl)phenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-bis(4-(trifluoromethyl)phenyl)propanenitrile(42134-72-5)
• EPA Substance Registry System: 2,3-bis(4-(trifluoromethyl)phenyl)propanenitrile(42134-72-5)

Safety Data

• Hazardous Substances Data: 42134-72-5(Hazardous Substances Data)

Upstream product

• 77287-34-4 formamide 
• 119757-51-6 1,2-bis(4-(trifluoromethyl)phenyl)ethyne 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 143-33-9 sodium cyanide 
• 939-99-1 4-trifluoromethylbenzyl chloride 

Relevant articles and documents

Nickel/Cobalt-Catalyzed Reductive Hydrocyanation of Alkynes with Formamide as the Cyano Source, Dehydrant, Reductant, and Solvent

A Ni/Co co-catalyzed reductive hydrocyanation of various alkynes was developed for the production of saturated nitriles. Hydrocyanic acid is generated in situ from safe and readily available formamide. Formamide played multiple roles as a cyano source, dehydrant, and reductant for the NiII pre-catalyst and vinyl nitriles, along with acting as the co-solvent in this reaction. Detailed mechanistic investigation supported a pathway via hydrocyanation of C≡C bond and the subsequent reduction of C=C bond. Wide substrate scope, the employment of a cheap and stable nickel salt as pre-catalyst, a safe cyano source and convenient experimental operation render this hydrocyanation practical for the laboratory synthesis of saturated nitriles. (Figure presented.).