42144-78-5Relevant articles and documents
Synthesis method and aftertreatment process of 6-chloro-2-hydrocarbyloxy pyridine
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Paragraph 0045-0050; 0065-0067, (2018/06/15)
The invention relates to a synthesis method and an aftertreatment process of 6-chloro-2-hydrocarbyloxy pyridine. The synthesis method is characterized in that 2,6-dichloropyridine, alcohol and alkaliare used as starting raw materials; reaction is performed under the ordinary pressure and backflow state to generate 6-chloro-2-hydrocarbyloxy pyridine; the reaction conditions are mild; high conversion rate and high selectivity of the reaction are realized. The invention also relates to a treatment technology after reaction; the aftertreatment technology is simple and efficient; the circulation process is reasonably utilized for treating solid wastes and solvents; the environment protection problem in the aftertreatment process is creatively solved.
Novel synthesis method for ortho-alkane superseded pyridine
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Paragraph 0018; 0019; 0020; 0021, (2017/07/19)
The invention relates to a novel synthesis method for ortho-alkane superseded pyridine. According to the method, ortho halogenated pyridine serves as raw materials, the ortho halogenated pyridine and corresponding alcohol react to obtain the ortho-alkane superseded pyridine under the action of sodium hydroxide. The reaction has universality for the ortho halogenated pyridine, and the method is simple and practical. Influence of consumption of the sodium hydroxide on mono-substitution and di-substitution in the reaction is inspected, alkoxy mono-substitution products and alkoxy di-substitution production are acquired, and a novel simply-operated, economical and favorable process for synthesis ortho-alkane superseded pyridine is provided.
TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS
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Page/Page column 98, (2016/03/19)
A compound of formula I wherein: n is 1 or 2: p is 0 or 1; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.