42150-17-4Relevant articles and documents
Hydrogenative Kinetic Resolution of Vinyl Sulfoxides
Lao, Joan R.,Fernndez-Prez, Hctor,Vidal-Ferran, Anton
supporting information, p. 4114 - 4117 (2015/09/01)
Enantiopure sulfoxides are valuable precursors of organosulfur compounds with broad application in organic and pharmaceutical chemistry. An unprecedented strategy for obtaining highly enantioenriched sulfoxides based on a hydrogenative kinetic resolution using Rh-complexes of phosphine-phosphite ligands as catalysts is reported. After optimization, highly efficient conditions for the kinetic resolution of racemic sulfoxides have been identified. This methodology has been applied to a set of racemic aralkyl or aryl vinyl sulfoxides and allowed the isolation of both recovered and reduced products in excellent yields and enantioselectivities (up to 99% and 97% ee, respectively; 16 examples).
SINGLE-STAGE SYNTHESIS OF VINYL SULFIDES FROM HALOGEN DERIVATIVES, ACETYLENES, AND SODIUM SULFIDE
Nosyreva, V. V.,Amosova, S. V.,Trofimov, B. A.
, p. 1770 - 1774 (2007/10/02)
The vinylthiylation of halogen-containing compounds by acetylenes in the presence of sodium sulfide was realized.The effect of the ratio of ethylene chlorohydrin and sodium sulfide, the concentration of water, the order in which the initial reagents are mixed, and the reaction temperature on the yield of the vinyl sulfides was investigated.
