4224-70-8 Usage
Description
6-Bromohexanoic acid is an organobromine compound that consists of hexanoic acid with a bromo substituent at the 6-position. It is characterized by its white to light orange color and low melting crystals.
Uses
Used in Organic Synthesis:
6-Bromohexanoic acid is used as an intermediate in organic synthesis for the preparation of various compounds, including N-acylsulfonamides, diarylthioethers, and 2-lithio-1,3-dithian. It plays a crucial role in the synthesis of these compounds due to its unique chemical properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-Bromohexanoic acid is used as a starting material for the synthesis of N-acylsulfonamides, which are important in the treatment of various medical conditions. The acid is also used in the preparation of alkyl ketones from alkyl iodides and metallic strontium, which can be further utilized in the development of pharmaceutical compounds.
Used in Chemical Research:
6-Bromohexanoic acid is employed in chemical research for the synthesis of anionic mitomycin C-dextran conjugate (MMC-D), which is a potential candidate for targeted drug delivery systems. Its unique chemical properties make it a valuable compound for exploring new synthetic pathways and developing novel applications in the chemical and pharmaceutical industries.
Organic Intermediate
6-bromohexanoic acid, also called 6-bromohexanoic acid or 6-bromo-hexanoic acid, is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. 6-Bromohexanoic acid is used in the preparation of N-acylsulfonamides, diarylthioethers and 2-lithio-1,3-dithian. It is widely used as an intermediate in organic synthesis. Here, we introduced a method for making this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 4224-70-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,2 and 4 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4224-70:
(6*4)+(5*2)+(4*2)+(3*4)+(2*7)+(1*0)=68
68 % 10 = 8
So 4224-70-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H11BrO2/c7-5-3-1-2-4-6(8)9/h1-5H2,(H,8,9)/p-1
4224-70-8Relevant articles and documents
Galli et al.
, p. 8374,8375, 8376, 8378 (1973)
DMF-mediated deprotection of bulky silyl esters under neutral and fluoride-free conditions
Chen, Bo,Sun, Hui-Xia,Qin, Jian-Feng,Wang, Bing
, p. 253 - 255 (2016/01/12)
Bulky TBDPS and TIPS carboxylic esters were efficiently cleaved by a green and mild protocol using only DMF-H2O (20:1) at 70 °C. The neutral conditions tolerate various common acid- and base-labile functionalities, including alkyl and aryl silyl ethers.
A new phenylethyl alkyl amide from the Ambrostoma quadriimpressum Motschulsky
Zhao, Guolei,Yang, Chao,Li, Bing,Xia, Wujiong
supporting information; experimental part, p. 1342 - 1346 (2011/11/14)
A new phenylethyl alkyl amide, (10R)-10-hydroxy-N-phenethyloctadecanamide (1), was isolated from the beetle Ambrostoma quadriimpressum Motschulsky. The structure of the amide was determined by NMR and MS. The absolute configuration of compound 1 was confirmed by an asymmetric total synthesis, which was started from L-glutamic acid. The construction of the aliphatic chain was accomplished by the selective protection of the hydroxy groups and two-time implementation of the Wittig olefination reaction.