42247-74-5Relevant articles and documents
A copper catalyzed novel method for synthesizing benzonitrile derivatives (by machine translation)
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Paragraph 0050; 0051; 0052; 0053, (2016/10/09)
The invention relates to a copper catalyzed novel method for synthesizing benzonitrile derivatives. The method is to Benzylether or benzaldehyde compound as a substrate, the copper salt as catalyst condition, with the nitrogen source at certain temperature to prepare the benzonitrile derivatives. Synthesis of of the present invention compared with the previous method, only the one-step reaction steps, reaction time is relatively short, simple treatment after the mild reaction conditions. The present invention uses wider range of the substrate, including benzaldehyde class Benzylether and, in ethers as the substrate is used to synthesize a nitrile compounds has never been reported before, and the reaction time as the substrate benzaldehyde class without side reaction to occur, the separation of product to reach the highest yield 94%. (by machine translation)
Nucleotide. XIV. Substituierte β-Phenylaethyl-Gruppen. Neue Schutzgruppen fuer Oligonucleotid-Synthesen nach dem Phosphorsaeuretriester-Verfahren
Uhlmann, Eugen,Pfleiderer, Wolfgang
, p. 1688 - 1703 (2007/10/02)
Various o- and p-substituted β-phenylethanols (2-10) have been synthesized and investigated as blocking groups in the phosphotriester approach.A large number of 5'-O-tritylated thymidine-3'-phosphotriesters (13-36) with two different phosphate protecting groups have been prepared, characterized, and studied according to their chemical stability and usefullness for oligonucleotide syntheses.The combination of a 5'-O-monomethoxytrityl- and a 3'-(2,5-dichlorophenyl, p-nitrophenylethyl)-phosphate function as in 18 turned out to possess optimal properties as a monomeric nucleotide building block due to the fact that these blocking groups can be quantitatively and selectively be removed without harming each other by trifluoroacetic acid in chloroform to 41, by oximate to 42, and by DBU to 43.The base-catalyzed removal of the monosubstituted phenylethyl groups by DBU or DBN respectively as well as the disubstituted phenylethyl groups by triethylamine in aprotic solvents is a β-elimination process leading to phosphodiesters without attack on the P-center.