4225-16-5

Basic information

• Product Name: Benzothiazole, 5-chloro-2-(dimethylamino)- (7CI,8CI)
• Synonyms: Benzothiazole, 5-chloro-2-(dimethylamino)- (7CI,8CI)
• CAS NO: 4225-16-5
• Molecular Formula: C9H9ClN2S
• Molecular Weight: 212.69916
• Product Categories: BENZOTHIAZOLE
• Mol File: 4225-16-5.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzothiazole, 5-chloro-2-(dimethylamino)- (7CI,8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 5-chloro-2-(dimethylamino)- (7CI,8CI)(4225-16-5)
• EPA Substance Registry System: Benzothiazole, 5-chloro-2-(dimethylamino)- (7CI,8CI)(4225-16-5)

Safety Data

• Hazardous Substances Data: 4225-16-5(Hazardous Substances Data)

Upstream product

• 2941-48-2 2,5-Dichloro-benzothiazole 
• 124-40-3 dimethyl amine 
• 6828-35-9 5-chloro-2-iodoaniline 
• 16420-13-6 N,N-Dimethylthiocarbamoyl chloride 
• 95-82-9 2,5 dichloroaniline 
• 16906-70-0 phenyl N,N-dimethyl dithiocarbamate 
• 1004-00-8 4-chloro-2-aminobenzenethiol 
• 128-04-1 sodium dimethyldithiocarbamate 

Relevant articles and documents

Metal-free or transition-metal-catalyzed one-pot synthesis of 2-aminobenzothiazoles

A series of 2-aminobenzothiazoles were synthesized by using 2-halogen-substituted anilines (halogen = Cl, Br, I) and dithiocarbamates in the presence of KOt-Bu. This simple and efficient protocol lets the reactions undergo in a smooth and rapid way to afford the corresponding 2-aminobenzothiazoles in good yields. It is noteworthy that the present process allows the construction of 2-aminobenzothiazoles from a wide range of 2-halogen-substituted aniline derivatives, including substituted 2-iodoanilines, 2-bromoanilines and 2-chloroanilines.

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TETRAHYDROBENZOFURO[2,3-C]PYRIDINE AND BETA-CARBOLINE COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES

The present invention relates to novel compounds of formula (I) that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).

Method for catalytically synthesizing 2-aminobenzothiazole derivative by N, N-dimethylthio carbamoyl chloride under microwave radiation

The invention discloses a method for catalytically synthesizing a 2-aminobenzothiazole derivative under microwave radiation. A catalytic amount of copper iodide serving as a catalyst, 8-hydroxyquinoline serving as a ligand, potassium hydroxide serving as an auxiliary catalyst, 2-halogenated aniline, a derivative of 2-halogenated aniline, powdered sulfur, an N, N-dimethylthio carbamoyl chloride derivative and pyridine are added into a reaction vessel, the reaction vessel is placed into a microwave reactor, reaction is performed at a certain temperature and under a certain power, vacuum concentration is performed after a certain time, and a product is purified by column chromatography. According to the method, raw materials are novel, operation is simple and convenient, and the 2-aminobenzothiazole derivative is efficiently prepared. Compared with the prior art, the method has the advantages that reaction speed is obviously increased as compared with conventional heating, reaction conditions are mild, and the method is simple in operation, high in yield, safe, low in cost and environmentally friendly.