42268-62-2Relevant articles and documents
Efficient Conversion of Tertiary Propargylamides into Imidazoles via Hydroamination-Cyclization
Safrygin, Alexander,Krivosheyeva, Elena,Dar'in, Dmitry,Krasavin, Mikhail
, p. 3048 - 3058 (2018/07/02)
A method to convert tertiary N -propargylamides into 1,2,4-trisubstituted imidazoles using ammonium chloride and zinc triflate as the catalyst is reported. The method is convenient, practical and employs conventional heating. It is also applicable to N -propargyl lactams and tends to populate the so-called 'lead-like' chemistry space.
Ultrasound promoted the synthesis of N-propargylic β-enaminones
Martins, Marcos A.P.,Rossatto, Marcelo,Prola, Liziê D.T.,Pizzuti, Lucas,Moreira, Dayse N.,Campos, Patrick T.,Frizzo, Clarissa P.,Zanatta, Nilo,Bonacorso, Helio G.
experimental part, p. 227 - 231 (2012/04/10)
The synthesis of 14 novel N-propargylic β-enaminones from the reaction of β-alkoxy vinyltrihalomethyl[carboxyethyl] ketones [R 3C(O)CHC(R1)OMe, where R3 = CF3, CCl3, CO2Et and R1 = Me, Et, Pr, Bu, i-Pent, CH2CH2CO2Me] with propargyl amines [R 2NHCH2CCH, where R2 = Pr, PhCH2] is reported. Yields, solvents and reaction times needed for reaction completion, by microwave irradiation (MW), conventional thermal heating (TH) and under ultrasound irradiation (US) are compared. The best results were obtained under US irradiation in good to excellent yields (70-93%).
Organolanthanide-catalyzed intra- and intermolecular tandem C-N and C-C bond-forming processes of aminodialkenes, aminodialkynes, aminoalkeneynes, and aminoalkynes. New regiospecific approaches to pyrrolizidine, indolizidine, pyrrole, and pyrazine skeleto
Li, Yanwu,Marks, Tobin J.
, p. 1757 - 1771 (2007/10/03)
This contribution describes catalytic tandem C-N and C-C bond-forming reactions involving the intramolecular hydroamination/bicyclization and intermolecular hydroamination/cyclization of olefins and alkynes using the organolanthanide complexes Cp'2/
