42275-92-3

Basic information

• Product Name: 2-CHLORO-N-ISOPROPYLPROPANAMIDE
• Synonyms: 2-CHLORO-N-ISOPROPYLPROPANAMIDE;propanamide, 2-chloro-N-(1-methylethyl)-;2-chloro-N-isopropylpropanamide(SALTDATA: FREE);2-chloro-N-isopropyl-propionamide
• CAS NO: 42275-92-3
• Molecular Formula: C₆H₁₂ClNO
• Molecular Weight: 149.62
• Mol File: 42275-92-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 251.6°C at 760 mmHg
• Flash Point: 106°C
• Appearance: /
• Density: 1.027g/cm³
• Vapor Pressure: 0.0203mmHg at 25°C
• Refractive Index: 1.438
• CAS DataBase Reference: 2-CHLORO-N-ISOPROPYLPROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-ISOPROPYLPROPANAMIDE(42275-92-3)
• EPA Substance Registry System: 2-CHLORO-N-ISOPROPYLPROPANAMIDE(42275-92-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 42275-92-3(Hazardous Substances Data)

Usage

General Description

2-CHLORO-N-ISOPROPYLPROPANAMIDE is a chemical compound with the molecular formula C6H12ClNO and a molecular weight of 151.61 g/mol. It is a white to light yellow solid that is soluble in water and has a mild, characteristic odor. 2-CHLORO-N-ISOPROPYLPROPANAMIDE is commonly used as an intermediate in the synthesis of pharmaceutical and agrochemical products. It is also used as a building block in the production of various organic compounds. 2-CHLORO-N-ISOPROPYLPROPANAMIDE is known to have potential toxic and irritating effects on the respiratory system and skin, and proper safety precautions should be taken when handling and using this chemical.

InChI:InChI=1/C6H12ClNO/c1-4(2)8-6(9)5(3)7/h4-5H,1-3H3,(H,8,9)

Upstream product

• 7623-09-8 2-chloropropionyl chloride 
• 75-31-0 isopropylamine 

Downstream Products

• 162375-39-5 N-isopropyl-2-(phenylthio)propanamide 
• 162375-31-7 N-iso-propyl-Z-3-chloro-2-(phenylthio)propenamide 

Relevant articles and documents

Palladium-Catalyzed β-C(sp3)-H Arylation of Aliphatic Ketones Enabled by a Transient Directing Group

The direct arylation of aliphatic ketones has been developed via Pd-catalyzed β-C(sp3)-H bond functionalization with 2-(aminooxy)-N,N-dimethylacetamide as a novel transient directing group (TDG), which showed remarkable directing ability to generate arylated products in moderate to good yields. Furthermore, the reaction can tolerate abundant substrate of ketones and aryl iodides. This study expands the scope of applications for TDGs.

Investigation of the synthetic and mechanistic aspects of the highly stereoselective transformation of α-thioamides to α-thio-β- chloroacrylamides

Treatment of a series of α-thioamides with N-chlorosuccinimide results in efficient transformation to the analogous α-thio-β- chloroacrylamides. The mechanistic pathway has been established through isolation and characterisation of intermediate compounds. The scope of the transformation has been explored - aryl and alkylthio substituents, primary, secondary and tertiary amides can be employed. In most instances, the chloroacrylamides are formed exclusively as the Z-stereoisomer; however, with tertiary propanamides or with amides derived from butanoic or pentanoic acid a mixture of E- and Z-stereoisomers is formed. The Royal Society of Chemistry.