423165-35-9

Basic information

• Product Name: 1-bromo-2-isopropoxy-4-nitrobenzene
• Synonyms: 1-bromo-2-isopropoxy-4-nitrobenzene
• CAS NO: 423165-35-9
• Molecular Weight: 260.087
• Mol File: 423165-35-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-bromo-2-isopropoxy-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-isopropoxy-4-nitrobenzene(423165-35-9)
• EPA Substance Registry System: 1-bromo-2-isopropoxy-4-nitrobenzene(423165-35-9)

Safety Data

• Hazardous Substances Data: 423165-35-9(Hazardous Substances Data)

Usage

Functional groups

Nitrobenzene derivative, Bromine atom, Isopropoxy group

Position of functional groups

Bromine at 1-position, Isopropoxy at 2-position, Nitro at 4-position

Usage

Organic synthesis, Pharmaceutical and agrochemical preparation, Dye, Pesticide, and other organic compound synthesis

Physical state

Yellow solid

Odor

Slightly fruity

Hazardous nature

Considered hazardous, requires careful handling and safety precautions

Upstream product

• 75-30-9 2-iodo-propane 
• 52427-05-1 2-bromo-5-nitrophenol 
• 554-84-7 meta-nitrophenol 
• 77337-82-7 1-bromo-2-methoxy-4-nitrobenzene 
• 121-88-0 5-Nitro-2-aminophenol 

Downstream Products

• 753031-08-2 2-isopropoxy-4-nitrostyrene 
• 1336905-20-4 6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid 
• 1336905-22-6 methyl 6-bromo-3-methyl-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate 
• 1336905-24-8 methyl 6-bromo-3-(bromomethyl)-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate 
• 1336905-30-6 methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate 
• 1336905-32-8 3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid 
• 1336962-17-4 3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide 
• 1336905-27-1 methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-6-bromo-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate 
• 1336905-28-2 methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-[(1-methylethyl)oxy]-6-(2-oxo-1-pyrrolidinyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate 
• 1336905-29-3 3-(1,4'-bipiperidin-1'-ylmethyl)-7-[(1-methylethyl)oxy]-6-(2-oxo-1-pyrrolidinyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid 
• 1336962-25-4 3-(1,4'-bipiperidin-1'-ylmethyl)-7-[(1-methylethyl)oxy]-6-(2-oxo-1-pyrrolidinyl)-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide 
• 1336966-95-0 methyl 3-(1,4'-bipiperidin-1'-ylmethyl)-7-[(1-methylethyl)oxy]-6-(1-pyrrolidinyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate 
• 1336966-98-3 3-(1,4'-bipiperidin-1'-ylmethyl)-7-[(1-methylethyl)oxy]-6-(1-pyrrolidinyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid 
• 1336962-46-9 3-(1,4'-bipiperidin-1'-ylmethyl)-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-6-(1-pyrrolidinyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide 

Relevant articles and documents

AMINOTRIAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES

The invention relates to triazole compounds of formula (I') or pharmaceutically acceptable salts thereof, useful as modulators of demyelinating diseases: wherein A is selected from the group consisting of (i), (ii), (iii), (iv), (v), and (vi) The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention, methods of using the compositions and kits thereof in the treatment of various demyelinating and neurodegenerative diseases, including multiple sclerosis.

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives

4,4″-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Plasmodium falciparum, and Leishmania amazonensis. Twenty-three compounds were highly active against T. b. rhodesiense or P. falciparum. Most noteworthy were amidines 1, 10, and 11 with IC50 of 4 nM against T. b. rhodesiense, and dimethyltetrahydropyrimidinyl analogues 4 and 9 with IC50 values of ≤ 3 nM against P. falciparum. Bis-pyridylimidamide derivative 31 was 25 times more potent than benznidazole against T. cruzi and slightly more potent than amphotericin B against L. amazonensis. Terphenyldiamidine 1 and dipyridylbenzene analogues 23 and 25 each cured 4/4 mice infected with T. b. rhodesiense STIB900 with four daily 5 mg/kg intraperitoneal doses, as well as with single doses of ≤10 mg/kg. Derivatives 5 and 28 (prodrugs of 1 and 25) each cured 3/4 mice with four daily 25 mg/kg oral doses.

Nitro-substituted Hoveyda-Grubbs ruthenium carbenes: Enhancement of catalyst activity through electronic activation

The design, synthesis, stability, and catalytic activity of nitro-substituted Hoveyda-Grubbs metathesis catalysts are described. The highly active and stable meta- and para-substituted complexes are attractive from a practical point of view. These catalys