42346-68-9

Basic information

• Product Name: 1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID
• Synonyms: 1-METHYL-5-OXO-3-PYRROLIDINECARBOXYLIC ACID;1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID;AKOS BB-8929;ASISCHEM C56784;1-methyl-4-carboxy-2-pyrrolidone;1-methyl-5-oxo-3-pyrrolidinecarboxylicaci;1-Methyl-5-oxopyrrolidine-3-carboxylic acid 97%;1-methyl-5-oxo-3-pyrrolidinecarboxylic acid(SALTDATA: FREE)
• CAS NO: 42346-68-9
• Molecular Formula: C6H9NO3
• Molecular Weight: 143.14
• EINECS: 255-765-5
• Product Categories: Carboxylic Acids;Pyrrolidines;Carboxylic Acids;Esters
• Mol File: 42346-68-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 361.7 °C at 760 mmHg
• Flash Point: 172.5 °C
• Appearance: /
• Density: 1.319 g/cm³
• Vapor Pressure: 3.26E-06mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID(42346-68-9)
• EPA Substance Registry System: 1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID(42346-68-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 42346-68-9(Hazardous Substances Data)

Usage

Description

1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID, also known as ondansetron, is a synthetic compound with potent antiemetic properties. It is a selective serotonin 5-HT3 receptor antagonist, which helps in blocking the action of serotonin, a neurotransmitter that can cause nausea and vomiting. 1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID is characterized by its ability to provide relief from chemotherapy-induced nausea and vomiting, making it a valuable asset in the field of oncology.

Uses

Used in Pharmaceutical Industry:
1-METHYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID is used as an active pharmaceutical ingredient for the treatment of chemotherapy-induced nausea and vomiting. Its application as an ondansetron in-adhesive transdermal patch allows for a non-invasive and convenient method of administration, providing continuous and controlled release of the drug to effectively manage nausea and vomiting associated with cancer treatments.

InChI:InChI=1/C6H9NO3/c1-7-3-4(6(9)10)2-5(7)8/h4H,2-3H2,1H3,(H,9,10)

Upstream product

• 97-65-4 2-methylenesuccinic acid 
• 74-89-5 methylamine 
• 59857-86-2 (±)-methyl 1-methyl-5-oxo-pyrrolidine-3-carboxylate 
• 617-52-7 Dimethyl itakonate 

Downstream Products

• 304858-50-2 1-methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide 
• 1291486-24-2 1-methyl-5-oxo-pyrrolidine-3-carbonyl chloride 
• 304858-62-6 N-(2-hydroxyethyl)-1-methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide 
• 304858-68-2 1-methyl-5-oxo-N-(3-oxopropyl)-N-phenylpyrrolidine-3-carboxamide 
• 304858-54-6 N-(3-chloropropyl)-1-methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide 
• 679003-57-7 2-{[(1-methyl-5-oxopyrrolidin-3-yl)carbonyl]-anilino}acetic acid 
• 679003-56-6 ethyl 2-{[(1-methyl-5-oxopyrrolidin-3-yl)carbonyl]-anilino}acetate 
• 304858-56-8 N-(4-chlorobutyl)-1-methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide 
• 304858-58-0 N-(5-chloropentyl)-1-methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide 
• 863024-33-3 N-[2-(1,3-dioxolan-2-yl)ethyl]-1-methyl-5-oxo-N-phenyl-pyrrolidine-3-carboxamide 
• 304859-35-6 N-[3-(4-benzylpiperazin-1-yl)propyl]-1-methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide 
• 780027-26-1 N-[3-(4-benzylpiperidin-1-yl)propyl]-1-methyl-N-(3-methylphenyl)-5-oxopyrrolidine-3-carboxamide 

Relevant articles and documents

Synthetic approaches to 10-azaprostaglandins

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MIXTURES OF ITACONIC ACID OR ITACONIC ACID DERIVATIVES AND PRIMARY AMINES FOR PRODUCING 1,3- AND 1,4-ALKYL METHYL PYRROLIDONES

The present invention relates to a mixture comprising itaconic acid or an itaconic acid derivative and a primary amine of the formula (I) [in-line-formulae]R—NH2??(I)[/in-line-formulae] where the molar ratio of primary amine to itaconic acid or the itaconic acid derivative is in the range from 0.5:1 to 20:1, wherein the mixture comprises 50 mole percent or less of 4-carboxypyrrolidones of the formula (II), derivatives of the 4-carboxypyrrolidones of the formula (II) and 4-carbamidopyrrolidones of the formula (III) based on the itaconic acid used or the itaconic acid derivative used and in which R is a linear or branched saturated aliphatic radical having 1 to 24 carbon atoms or a saturated cycloaliphatic radical having 3 to 24 carbon atoms. The invention further provides for the use of the inventive mixtures for preparing 1,3-alkylmethylpyrrolidones and/or 1,4-alkylmethylpyrrolidones, and also a process for preparing 1,3-alkylmethylpyrrolidones and/or 1,4-alkylmethylpyrrolidones. In addition, the present invention relates to mixtures comprising 1,3-alkylmethylpyrrolidones and/or 1,4-alkylmethylpyrrolidones and 1,3-alkylmethylpyrrolidines, where the proportion of 1,3-alkylmethylpyrrolidines is in the range from 10 to 10 000 ppm, and to mixtures comprising 1,3-alkylmethylpyrrolidone and 1,4-alkylmethylpyrrolidone, wherein the molar ratio of 1,3-alkylmethylpyrrolidone to 1,4-alkylmethylpyrrolidone is in the range from 1:1 to 10:1.