4237-52-9

Basic information

• Product Name: 1,2-Ethanediol, 2-(4-methoxyphenyl)-1,1-diphenyl-
• CAS NO: 4237-52-9
• Molecular Formula: C21H20O3
• Molecular Weight: 320.388
• Mol File: 4237-52-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-Ethanediol, 2-(4-methoxyphenyl)-1,1-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Ethanediol, 2-(4-methoxyphenyl)-1,1-diphenyl-(4237-52-9)
• EPA Substance Registry System: 1,2-Ethanediol, 2-(4-methoxyphenyl)-1,1-diphenyl-(4237-52-9)

Safety Data

• Hazardous Substances Data: 4237-52-9(Hazardous Substances Data)

Usage

Chemical structure

Diphenyl ether derivative with a 4-methoxyphenyl group attached to the 2-position of the 1,2-ethanediol backbone

Applications

Commonly used in the synthesis of organic compounds and pharmaceuticals

Potential uses

Drug development and material science

Reactivity

Unique structure and reactivity due to its chemical composition

Further research

May reveal additional benefits and uses for this compound

Upstream product

• 36141-66-9 ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 119-61-9 benzophenone 
• 123-11-5 4-methoxy-benzaldehyde 
• 25187-00-2 2-iodobenzophenone 

Downstream Products

• 5543-97-5 2-(4-methoxyphenyl)-1,2-diphenylethan-1-one 

Relevant articles and documents

Reductive coupling between aromatic aldehydes and ketones or imines by copper catalysis

The copper-catalyzed reductive coupling of two different carbonyl compounds has been achieved. The reaction of aromatic aldehydes and arylketones with a silylboronate in the presence of a catalytic amount of a CuCl-N-heterocyclic carbene (NHC) complex and a stoichiometric amount of alkoxide base yielded cross-coupled 1,2-diol derivatives. A reaction pathway is proposed that involves the catalytic formation of a nucleophilic α-silyloxybenzylcopper(I) species from the aromatic aldehyde and its subsequent coupling with the arylketone. This process was amenable to asymmetric catalysis. This copper catalyst system also enabled the reductive coupling between aromatic aldehydes and imines.