423737-44-4

Basic information

• Product Name: ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
• Synonyms: ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
• CAS NO: 423737-44-4
• Molecular Weight: 306.386
• Mol File: 423737-44-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate(423737-44-4)
• EPA Substance Registry System: ethyl 6-methyl-4-[4-(methylsulfanyl)phenyl]-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate(423737-44-4)

Safety Data

• Hazardous Substances Data: 423737-44-4(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Downstream Products

• 1017241-27-8 C₁₅H₁₈N₂O₄S 
• 1017241-28-9 C₁₅H₁₈N₂O₅S 
• 1451203-41-0 C₁₅H₁₆N₂O₃S 

Relevant articles and documents

2-oxo-1,2,3,4-tetrahydropyrimidines ethyl esters as potent β-glucuronidase inhibitors: One-pot synthesis, in vitro and in silico studies

Background: Glucuronidation is essential for the metabolism and excretion of toxic substances. β-Glucuronidase enzyme slows down the process of glucuronidation, and thus plays an important role in the on-set of colorectal carcinoma, and many other disease

A microwave-assisted, copper-catalyzed three-component synthesis of dihydropyrimidinones under mild conditions

The synthesis of dihydropyrimidinones via a clean multi-component Biginelli reaction under microwave irradiation is reported. The copper-catalyzed process proved to be simple, efficient, economical, and environmentally friendly.

Microwave assisted synthesis of some novel pyrimidinones/thiones

A novel scries of 1-substituted-4-aryl-5-ethoxycarbonyl-6-mcthylpyrimidine- 2-ones/thiones are prepared in the one pot condensation of appropriate aldehyde, ethylacetoacetate and substituted urea in ethanol medium under microwave irradiation. The new compounds are well characterized by IR,1H NMR, mass spectra, C.H,N-analysis and in a typical example the structure was further confirmed by X-ray crystallographic data.