42420-13-3

Basic information

• Product Name: (3,4-dimethoxyphenyl)-1-(piperidine-1-yl)methan-1-one
• Synonyms: (3,4-dimethoxyphenyl)-1-(piperidine-1-yl)methan-1-one
• CAS NO: 42420-13-3
• Molecular Weight: 249.31
• Mol File: 42420-13-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (3,4-dimethoxyphenyl)-1-(piperidine-1-yl)methan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-dimethoxyphenyl)-1-(piperidine-1-yl)methan-1-one(42420-13-3)
• EPA Substance Registry System: (3,4-dimethoxyphenyl)-1-(piperidine-1-yl)methan-1-one(42420-13-3)

Safety Data

• Hazardous Substances Data: 42420-13-3(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 933-88-0 ortho-toluoyl chloride 
• 93-07-2 Veratric acid 
• 2591-86-8 N-Formylpiperidine 
• 83735-51-7 3,4-dimethoxybenzoic acid 2,5-dioxo-1-pyrrolidinyl ester 
• 10535-17-8 1-(3,4-dimethoxyphenyl)-2-(methoxyphenoxy)propane-1,3-diol 
• 10548-77-3 1-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propan-1-one 
• 22675-96-3 2-methoxyphenoxy-3',4'-dimethoxyacetophenone 
• 201230-82-2 carbon monoxide 
• 2859-78-1 4-Bromoveratrole 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 

Downstream Products

• 37673-07-7 2-(3,4-dimethoxyphenyl)-2-(piperidin-1-yl)acetonitrile 
• 109247-02-1 1-veratryl-piperidine 

Relevant articles and documents

Chemical conversion of β-O-4 lignin linkage models through Cu-catalyzed aerobic amide bond formation

Methods for conversion of the lignin β-O-4 models into amide derivatives and phenols have been developed, which is achieved via chemo-selective oxidation of the secondary benzylic alcohol and subsequent Cu-catalyzed aerobic amide bond formation.

Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation

A method for the metal-free reduction of carboxylic amides using oxalyl chloride as an activating agent and hydrogen as the final reductant is introduced. The reaction proceeds via the hydrogen splitting by B(2,6-F2-C6H3)3 in combination with chloride as the Lewis base. Density functional theory calculations support the unprecedented role of halides as active Lewis base components in the frustrated Lewis pair mediated hydrogen activation. The reaction displays broad substrate scope for tertiary benzoic acid amides and α-branched carboxamides.

Metal–Organic Framework Based on Copper and Carboxylate-Imidazole as Robust and Effective Catalyst in the Oxidative Amidation of Carboxylic Acids and Formamides

A metal–organic framework (MOF) based on copper and 1,3-bis(carboxymethyl)imidazole (bcmim) was prepared on a gram scale by using a precipitation method at room temperature. The Cu(bcmim)2MOF was shown to be an efficient catalyst for the preparation of amides through an oxidative coupling between carboxylic acids and formamides in the presence of an oxidant, such as tert-butyl hydroperoxide (TBHP). The method for the preparation of the amides is robust regardless of the carboxylic acid and gives good conversions with good selectivity. The heterogeneous catalyst was recovered unaltered after the reaction, was easily separated from the reaction mixture, and subsequently reactivated by suitable treatment. Moreover, the coupling reaction was scaled up to a gram scale, which allowed for the preparation of valuable products, such as fatty acid amides (i.e., 1-palmitoylpiperidine).