42447-82-5

Basic information

• Product Name: 3-(HYDROXYIMINO)-URS-12-EN-28-OIC ACID METHYL ESTER
• Synonyms: 3-(HYDROXYIMINO)-URS-12-EN-28-OIC ACID METHYL ESTER
• CAS NO: 42447-82-5
• Molecular Formula: C31H49NO3
• Molecular Weight: 0
• Mol File: 42447-82-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(HYDROXYIMINO)-URS-12-EN-28-OIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(HYDROXYIMINO)-URS-12-EN-28-OIC ACID METHYL ESTER(42447-82-5)
• EPA Substance Registry System: 3-(HYDROXYIMINO)-URS-12-EN-28-OIC ACID METHYL ESTER(42447-82-5)

Safety Data

• Hazardous Substances Data: 42447-82-5(Hazardous Substances Data)

Upstream product

• 989-72-0 methyl ursonate 
• 77-52-1 ursolic acid 
• 915-32-2 methyl (3β)-3-hydroxyurs-12-en-28-oate 

Relevant articles and documents

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The cytotoxic activity of ursolic acid derivatives

Ursolic acid and 2α-hydroxyursolic acid isolated from apple peels were found to show growth inhibitory activity against four tumor cell lines, HL-60, BGC, Bel-7402 and Hela. Structural modifications were performed on the C-3, C-28 and C-11 positions of ursolic acid and the cytotoxicity of the derivatives was evaluated. The SAR revealed that the triterpenes possessing two hydrogen-bond forming groups (an H-donor and a carbonyl group) at positions 3 and 28 exhibit cytotoxic activity. The configuration at C-3 was found to be important for the activity. Introduction of an amino group increased the cytotoxicity greatly. A 3β-amino derivative was 20 times more potent than the parent ursolic acid. The 28-aminoalkyl dimer compounds showed selective cytotoxicity.