4247-19-2

Basic information

• Product Name: 1,2,6,7-DIEPOXYHEPTANE
• Synonyms: 1,2,6,7-DIEPOXYHEPTANE;2,2'-(1,3-Propanediyl)bisoxirane;2,2'-(Trimethylene)bisoxirane;2,2'-Trimethylenebisoxirane
• CAS NO: 4247-19-2
• Molecular Formula: C7H12O2
• Molecular Weight: 128.19
• Mol File: 4247-19-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 177.6°C (rough estimate)
• Appearance: /
• Density: 0.9805 (rough estimate)
• Refractive Index: 1.4500 (estimate)
• CAS DataBase Reference: 1,2,6,7-DIEPOXYHEPTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,6,7-DIEPOXYHEPTANE(4247-19-2)
• EPA Substance Registry System: 1,2,6,7-DIEPOXYHEPTANE(4247-19-2)

Safety Data

• Hazardous Substances Data: 4247-19-2(Hazardous Substances Data)

Usage

General Description

1,2,6,7-Diepoxyheptane is a chemical compound with the molecular formula C7H14O2. It is a colorless liquid with a molecular weight of 130.18 g/mol. 1,2,6,7-Diepoxyheptane is used in the production of epoxy resins and as a crosslinking agent for polymers. It is also used in the synthesis of other organic compounds, such as pharmaceuticals and agrochemicals. The compound is considered to be moderately toxic, with potential for skin and eye irritation, and should be handled with care in a well-ventilated area. Its potential environmental impact is not well-documented, and further research is needed to understand its potential risks and hazards.

Upstream product

• 3070-53-9 1,6-heptadiene 

Relevant articles and documents

Synthesis and enantioselective gas chromatography of stereoisomers of 7,11-dimethylheptadecane - A pheromone component of Lambdina species

The stereoisomers of 7,11-dimethylheptadecane exhibit a useful level of separation under enantioselective gas chromatographic conditions, using a modified cyclodextrin phase. Synthesis of the (7R,11R) isomer and coinjection studies establish the order of elution as (7S,11S), (7R,11R), and finally the meso form, the latter being a sex-pheromone component of Lambdina species. Enantiomeric assays of natural samples containing this hydrocarbon system will now be possible. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Design and synthesis of new mitomycin dimers containing a seven-membered cyclic disulfide and a diol linkers

We report the design and synthesis of two new mitomycin dimers, 7-N,7′-N′-(1″,2″-dithiepanyl- 3″,7″- dimethylenyl)bismitomycin C (8) and 7-N,7′-N′-(2″,6″- dihydroxy-1″,7″-heptanediyl)bismitomycin C (9). Mitomycins 8 and 9 are dimers connected by a seven-membered cyclic disulfide (a 1,2-dithiepane) and a 2,6-dihydroxyheptane linkers, respectively. Mitomycin 8 was designed to undergo efficient nucleophilic activation and following alkylation to give DNA adducts such as DNA interstrand cross-link (DNA ISC) adducts. The key moiety in 8 is a seven-membered cyclic disulfide linker that can generate two thiol groups in a molecule through disulfide cleavage. The two thiols can serve as probes to activate two mitomycin rings by intramolecular cyclization to quinone rings. The mitomycin 8 was synthesized using mitomycin A (1) and the key intermediate, cyclic disulfide 11 that was prepared through a nine-step synthetic sequence from 1,6- heptadiene (12). The diol mitomycin 9 was also synthesized from 1 and diamine salt 15.