42472-96-8 Usage
Heterocyclic compound
A compound containing a ring structure with at least one heteroatom, which is an atom other than carbon, such as nitrogen or oxygen.
Piperidin-3-one moiety
A six-membered ring with a nitrogen atom at the 3-position and a ketone group (C=O) attached to the 2-position.
Isoindole-1,3-dione moiety
A bicyclic compound consisting of a six-membered aromatic ring with two oxygen atoms at the 1and 3-positions, forming a dione group.
Biological activity
The ability of the compound to interact with biological systems, such as cells, tissues, or organisms, and produce a measurable effect.
Pharmacological properties
The characteristics of the compound that make it suitable for use in the treatment or prevention of diseases or conditions.
Medicinal chemists
Scientists who study the chemical properties of compounds and their potential as therapeutic agents.
Pharmacologists
Scientists who study the effects of drugs on biological systems and their mechanisms of action.
Drug discovery and development
The process of identifying and developing new drugs for the treatment or prevention of diseases or conditions.
Therapeutic applications
The use of a compound to treat or prevent diseases or conditions, often through its biological activity and pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 42472-96-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,4,7 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 42472-96:
(7*4)+(6*2)+(5*4)+(4*7)+(3*2)+(2*9)+(1*6)=118
118 % 10 = 8
So 42472-96-8 is a valid CAS Registry Number.
42472-96-8Relevant articles and documents
Comparative teratological investigation of compounds structurally and pharmacologically related to thalidomide
Helm,Frankus,Friderichs,Graudums,Flohe
, p. 941 - 949 (2007/10/02)
Compounds differing from thalidomide in either the phthalimide or the 2,6-dioxopiperidine moiety of the molecule were synthetized and tested for teratogenic potency in White New Zealand rabbits. Both the 2,6-dioxopiperidine and 2-oxopiperidine derivatives of phthalimide and phthalimidine were found to be highly teratogenic. A somewhat higher teratogenic potential appeared to be associated with the 2,6-dioxopiperidine derivatives. The most potent teratogen investigated was clearly 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM 12). Compounds in which the phthalimide ring was replaced by 2,3-dihydro-1,1-dioxido-3-oxo-1,2-benzisothiazol, did not induce any embryopathic effect differing from control data. No consistent correlation between teratogenic activity and sedative properties of the compounds was detected. The results are discussed in respect to current views of the molecular mechanism leading to thalidomide embryopathy.
