42473-87-0

Basic information

• Product Name: 2-(4-ethoxyphenyl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(4-ethoxyphenyl)-1H-isoindole-1,3(2H)-dione
• CAS NO: 42473-87-0
• Molecular Formula: C₁₆H₁₃NO₃
• Molecular Weight: 267.27932
• Mol File: 42473-87-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 204-205 °C
• Boiling Point: 451.6±47.0 °C(Predicted)
• Appearance: /
• Density: 1.289±0.06 g/cm3(Predicted)
• PKA: 0.25±0.20(Predicted)
• CAS DataBase Reference: 2-(4-ethoxyphenyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethoxyphenyl)-1H-isoindole-1,3(2H)-dione(42473-87-0)
• EPA Substance Registry System: 2-(4-ethoxyphenyl)-1H-isoindole-1,3(2H)-dione(42473-87-0)

Safety Data

• Hazardous Substances Data: 42473-87-0(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 156-43-4 4-Ethoxyaniline 
• 150-75-4 N-methyl-p-aminophenol 
• 84-66-2 Diethyl phthalate 
• 7614-49-5 N-(4-Aethoxy-phenyl)-phthalamidsaeure 
• 62-44-2 4-ethoxyacetanilide 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 72873-49-5 4-(4-ethoxy-phenyl)-benzo[d][1,2]oxazin-1-one 
• 368-39-8 triethyloxonium fluoroborate 
• 67-56-1 methanol 
• 15484-91-0 N-benzylidene-4-ethoxyaniline 
• 136918-14-4 phthalimide 
• 103-73-1 Phenetole 

Downstream Products

• 7614-49-5 N-(4-Aethoxy-phenyl)-phthalamidsaeure 
• 89313-72-4 2-(4-ethoxyphenyl)isoindolin-1-one 

Relevant articles and documents

Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams

An efficient and practical electrochemical method for selective reduction of cyclic imides has been developed using a simple undivided cell with carbon electrodes at room temperature. The reaction provides a useful strategy for the rapid synthesis of hydroxylactams and lactams in a controllable manner, which is tuned by electric current and reaction time, and exhibits broad substrate scope and high functional group tolerance even to reduction-sensitive moieties. Initial mechanistic studies suggest that the approach heavily relies on the utilization of amines (e.g., i-Pr2NH), which are able to generate α-aminoalkyl radicals. This protocol provides an efficient route for the cleavage of C-O bonds under mild conditions with high chemoselectivity.

HYDROLYSIS OF 1-OXO-3-ETHYL-4-ARYL-2,3-BEZOXAZINIUM SALTS

Irrespective of the character of the substituent at position 4, the action of triethyloxonium fluoroborate on 1-oxo-4-aryl(methyl)-2,3-benzoxazines leads to the formation of 1-oxo-3-ethyl-4-aryl(methyl)-2,3-benzoxazinium tetrafluoroborates, which readily exchange the anion, being converted into the corresponding perchlorates and tetrachloroferrates.Hydrolysis of the oxobenzoxazinium perchlorates leads to 4-hydroxy-3-ethyl-4-aryl(methyl)-2,3-benzoxazin-1-ones, which exhibit the characteristics of carbinol bases.The formation of N-arylphthalimides is also observed in the case of the oxobenzoxazinium salts containing accepting or weakly don ating substituents.