42479-99-2

Basic information

• Product Name: Benzenepropanethioic acid, b-hydroxy-, S-(1,1-dimethylethyl) ester
• CAS NO: 42479-99-2
• Molecular Formula: C13H18O2S
• Molecular Weight: 238.351
• Mol File: 42479-99-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenepropanethioic acid, b-hydroxy-, S-(1,1-dimethylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanethioic acid, b-hydroxy-, S-(1,1-dimethylethyl) ester(42479-99-2)
• EPA Substance Registry System: Benzenepropanethioic acid, b-hydroxy-, S-(1,1-dimethylethyl) ester(42479-99-2)

Safety Data

• Hazardous Substances Data: 42479-99-2(Hazardous Substances Data)

Upstream product

• 463-51-4 Ketene 
• 43143-00-6 C₁₂H₂₇BS 
• 100-52-7 benzaldehyde 
• 999-90-6 S-tert-butyl thioacetate 
• 63584-47-4 (1-tert-butylsulfanyl-vinyloxy)trimethylsilane 
• 75-66-1 2-methylpropan-2-thiol 

Relevant articles and documents

Lithium acetate-catalyzed aldol reaction between aldehyde and trimethylsilyl enolate in anhydrous or water-containing N,N-dimethylformamide

Lithium acetate (AcOLi)-catalyzed aldol reactions between trimethylsilyl enolates and aldehydes proceed smoothly in anhydrous DMF or pyridine to afford the corresponding aldols in good to high yields under weakly-basic conditions (Tables 1-5). This cataly

Optimisation, scope and limitations of enantioselective aldol reactions of an S-ketene silyl acetal with aliphatic aldehydes under (R)-BINOL-titanium(IV) catalysis conditions

The Mukaiyama aldol reaction between the functionalised aldehydes 5 and the S-ketene silyl acetal 2 catalysed by 1,1'-binaphthyl-derived chiral titanium(IV) complex 4 afforded the corresponding aldol products 6 in good yields and with good to excellent enantioselectivities. The chemical yield could further be enhanced, without loss of stereoselection, by addition of phenol and/or molecular sieves. The presented aldol reactions with aluminium, boron and ytterbium-BINOL catalysts demonstrate that only low chiral induction can be achieved. Aldol product 6a was converted into an α-lipoic acid precursor 8, thus providing a formal synthesis of this biologically active compound. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).