42487-72-9

Basic information

• Product Name: 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE
• Synonyms: 2-DIETHYLAMINO-6-METHYL PYRIMIDIN-4-OL;2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE;2-(diethylamino)-6-methyl-1H-pyrimidin-4-one;2-(DIETHYLAMINO)-6-METHYLPYRIMIDIN-4-OL/ONE;2-(Diethylamino)-6-methyl-4(3H)-pyrimidinone;2-(Diethylamino)-6-methylpyrimidin-4(1H)-one;2-(Diethylamino)-6-methylpyrimidine-4-ol;2-Diethylamino-6-methyl-4-pyrimidinol
• CAS NO: 42487-72-9
• Molecular Formula: C9H15N3O
• Molecular Weight: 181.23
• EINECS: 255-848-6
• Mol File: 42487-72-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 133-134 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 266°Cat760mmHg
• Flash Point: 114.7°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 0.00887mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.28±0.50(Predicted)
• CAS DataBase Reference: 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE(42487-72-9)
• EPA Substance Registry System: 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE(42487-72-9)

Safety Data

• Hazardous Substances Data: 42487-72-9(Hazardous Substances Data)

Usage

Description

2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE is a heterocyclic compound characterized by the presence of two heteroatoms within its molecular structure. It possesses pharmacophoric properties, making it a valuable building block in the synthesis of various pharmaceutical agents.

Uses

Used in Pharmaceutical Industry:
2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE is used as a key intermediate in the synthesis of heterocyclic compounds for their potential therapeutic applications. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in HIV Treatment:
2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE is used as a precursor in the synthesis of dual inhibitors targeting the HIV-1 caspid and human cyclophilin A enzymes. These enzymes are crucial for the assembly and replication of HIV-1, making them important therapeutic targets for the development of antiretroviral drugs. By inhibiting both enzymes, these dual inhibitors can potentially enhance the effectiveness of HIV treatment and combat drug resistance.

InChI:InChI=1/C9H15N3O/c1-4-12(5-2)9-10-7(3)6-8(13)11-9/h6H,4-5H2,1-3H3,(H,10,11,13)

Upstream product

• 111697-06-4 2-N,N-diethylamino-4-methoxy-6-methylpyrimidine 
• 22536-64-7 2-chloro-4-methoxy-6-methyl-pyrimidine 
• 5949-29-1 citric acid monohydrate 
• 108-10-1 4-methyl-2-pentanone 
• 116312-14-2 1,1-diethylhydrazine hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 1187-09-3 1,1-diethylguanidine nitrate 
• 18240-93-2 1,1-diethylguanidine 

Downstream Products

• 29232-93-7 Pirimiphos-methyl 

Relevant articles and documents

Synthetic method of hydroxypyrimidine compound

The invention discloses a synthesis method of a hydroxypyrimidine compound, which comprises the following steps: adding alkyl guanidine salt into a methanol or ethanol solvent, adding a neutralizing reagent to carry out a neutralization reaction, filtering, and removing the solvent from the filtrate to obtain the residue alkyl guanidine; mixing alkyl guanidine with alkyl alpha-alkylacetoacetate, reacting in an inert atmosphere at 90-140 DEG C until water and methanol are separated, cooling to 60-80 DEG C after the reaction is finished, adding alkyl hydrocarbon into the reaction solution, stirring for 10-30 minutes, cooling to room temperature, filtering and washing to obtain the hydroxypyrimidine compound. According to the synthesis method, no solvent reaction exists, so that the single-kettle reaction efficiency is greatly improved; in addition, dehydration and degreasing are carried out in an inert atmosphere, so that deterioration of alkyl alpha-alkylacetoacetate at high temperatureis effectively avoided, and the reaction safety is also improved. Therefore, the synthesis method disclosed by the invention has the advantages of high single-kettle reaction efficiency, high safetyand less three wastes.

Acid dye for polyamide fiber dyeing and preparation method thereof (by machine translation)

The invention discloses an acid dye, for polyamide fiber dyeing, which has a chemical structural general formula of: R Is an aromatic sulfonic acid group . and the invention also provides a preparation method. of the acid dye, and the acid dye, prepared by the invention does not contain a heavy metal, as a novel acid dye and has excellent water treatment fastness, and bright color light. (by machine translation)

Pyrimidines. 8. Chlorination of 6-methyluracil with phosphorus oxychloride in the presence of trialkyamines

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