425394-89-4Relevant articles and documents
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors
Bajrami, Bekim,Bame, Eris,Gu, Chungang,Hoemberger, Marc,Hopkins, Brian T.,Huang, Jiansheng,Ma, Bin,Metrick, Claire M.,Mingueneau, Michael,Murugan, Paramasivam,Santoro, Joseph C.,Tang, Hao,Wang, Ti
supporting information, (2022/02/01)
BTK is a tyrosine kinase playing an important role in B cell and myeloid cell functions through B cell receptor (BCR) signaling and Fc receptor (FcR) signaling. Selective inhibition of BTK has the potential to provide therapeutical benefits to patients su
ANTIBACTERIAL COMPOUNDS
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Paragraph 00193, (2020/06/05)
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.
ANTIBACTERIAL COMPOUNDS
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Paragraph 00178, (2018/12/02)
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. Furthermore, the subject compounds and compositions are useful for the treatment of bacterial infection, such as urinary tract infection and the like.