42545-22-2

Basic information

• Product Name: 1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester
• Synonyms: 1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester;Dimethyl 1-methyl-1H-imidazole-4,5-dicarboxylate
• CAS NO: 42545-22-2
• Molecular Formula: C₈H₁₀N₂O₄
• Molecular Weight: 198
• Mol File: 42545-22-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 46-47℃
• Boiling Point: 321℃
• Flash Point: 148℃
• Appearance: /
• Density: 1.29
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester(42545-22-2)
• EPA Substance Registry System: 1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester(42545-22-2)

Safety Data

• Hazardous Substances Data: 42545-22-2(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester is a chemical compound with the molecular formula C8H10N2O4. It is a dimethyl ester derivative of imidazole-4,5-dicarboxylic acid, which is a heterocyclic compound with potential pharmaceutical applications. This chemical is often used as a building block in the synthesis of various pharmaceutical and biologically active compounds. It is also used in the research and development of new drugs and in the preparation of organic intermediates. Additionally, it can be used as a reactant in the production of other chemical compounds. Its properties and potential applications make it a valuable compound in the fields of pharmaceuticals, organic chemistry, and drug discovery.

Upstream product

• 408351-07-5 1-methyl-2-thioxo-2,3-dihydro-1H-imidazole-4,5-dicarboxylic acid dimethyl ester 
• 3304-70-9 dimethyl imidazole-4,5-dicarboxylate 
• 74-88-4 methyl iodide 
• 570-22-9 4,5-imidazoledicarboxylic acid 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 67751-25-1 1-dimethylamino-1,2-di(methoxycarbonyl)ethene 

Downstream Products

• 19485-38-2 1-methyl-1H-imidazole-4,5-dicarboxylic acid 
• 81609-12-3 1,2,3,6-tetrahydro-1,2,7-trimethylimidazo-3,6-pyridazinedione 
• 86281-16-5 N,N-dicyclohexyl-1-methyl-4,5-imidazoledicarboxamide 
• 42190-84-1 1-methyl-4,5-imidazoledicarbonyl chloride 

Relevant articles and documents

A direct cycloaminative approach to imidazole derivatives via dual C-H functionalization

Organoiodine(III)-promoted C(sp3)-H azidation was a key step for the cycloaminative process. An unprecedented method for metal-free dehydrogenative N-incorporation into C(sp3)-H and C(sp2)-H bonds for the synthesis of diverse imidazoles has been disclosed. The overall transformation involves the construction of four C-N bonds through hydroamination-azidation-cyclization sequence. The reaction can be easily handled and proceeds under mild conditions. Further, the potential of the present strategy is revealed by the practical synthesis of N-heterocyclic carbene (NHC) precursors.

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.

1-ALKYL- AND 1-GLUCOSYL-4,5-IMIDAZOLEDICARBOXAMIDES

Among 4,5-imidazoledicarboxamides compounds were found which possess clearly defined neurotropic activity.In order to study the relation between the structure and the activity a series a new 4,5-imidazoledicarboxamides substituted in the amide groups and at the nitrogen of the imidazole ring were obtained.Their syntheses and characteristics are described.