425644-16-2Relevant articles and documents
Synthesis and opioid activity of new fentanyl analogs
Giron, Rocio,Abalo, Raquel,Goicoechea, Carlos,Martin, Ma Isabel,Callado, Luis F,Cano, Carolina,Goya, Pilar,Jagerovic, Nadine
, p. 1023 - 1034 (2002)
Three new fentanyl analogs (compounds 3-4-5) have been synthesized and evaluated for antinociceptive properties using the writhing test. The analgesic property of the active compound, N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl)] propenamide (
Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.
Jagerovic, Nadine,Cano, Carolina,Elguero, Jose,Goya, Pilar,Callado, Luis F,Meana, J Javier,Giron, Rocio,Abalo, Raquel,Ruiz, David,Goicoechea, Carlos,Martin, M A Isabel
, p. 817 - 827 (2007/10/03)
The synthesis of new fentanyl analogues in which the benzene ring of the propioanilido group has been replaced by phenylpyrazole is described. Antinociceptive activity was evaluated using the writhing and hot plate tests in mice. Two compounds, and, showe