4257-82-3

Basic information

• Product Name: 2,2,2-Trichloro-N-(2-methoxyphenyl)acetamide
• Synonyms: 2,2,2-Trichloro-N-(2-methoxyphenyl)acetamide;AcetaMide, 2,2,2-trichloro-N-(2-Methoxyphenyl)-
• CAS NO: 4257-82-3
• Molecular Formula: C₉H₈Cl₃NO₂
• Molecular Weight: 268.52
• Mol File: 4257-82-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2,2-Trichloro-N-(2-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trichloro-N-(2-methoxyphenyl)acetamide(4257-82-3)
• EPA Substance Registry System: 2,2,2-Trichloro-N-(2-methoxyphenyl)acetamide(4257-82-3)

Safety Data

• Hazardous Substances Data: 4257-82-3(Hazardous Substances Data)

Usage

Physical form

White crystalline solid

Molecular weight

193.55 g/mol

Chemical classification

Amide derivative

Structural features

Contains three chlorine atoms, a methoxy group, and a phenyl group

Usage

Commonly used as a pharmaceutical intermediate in the synthesis of various drugs and medications

Properties

Exhibits antibacterial and antifungal properties, making it a valuable component in the development of antimicrobial agents

Industrial and pharmaceutical applications

Has several important applications in these fields

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 76-03-9 trichloroacetic acid 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 107620-46-2 1-Benzolsulfonyl-3-<2-methoxy-phenyl>-harnstoff 
• 1226-63-7 1,3-bis(2-methoxyphenyl)urea 
• 113260-69-8 1-Benzoyl-3-(2-methoxy-phenyl)-urea 
• 1228763-37-8 N-(2-methoxyphenyl)dichloroacetimidoyl chloride 
• 1228757-55-8 N-(2-methoxyphenyl)-O-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl) dichloroacetimidate 

Relevant articles and documents

N-aryl-O-glycosyl haloacetimidates as glycosyl donors

Reaction of 1-O-unprotected tetra-O-acetyl- and tetra-O-benzyl- glucopyranose with N-aryl haloacetimidoyl chlorides in the presence of sodium hydride and 15-crown-5 afforded N-aryl-O-glucopyranosyl haloacetimidates. Mainly the β-anomers were obtained in this anomeric O-acylation-type reaction. The glycosyl donor properties of these haloacetimidates were investigated with 6-O- and 4-O-unprotected glucopyranosides as acceptors. The results were compared with those obtained with the corresponding O-glucopyranosyl trichloroacetimidates as glycosyl donors and the same acceptors. It was found that N-(2-chloro-6-methylphenyl)-O-glucopyranosyl trifluoroacetimidates (16Ad, 16Bd) exhibit glycosyl donor properties closely related to those of the corresponding N-unsubstituted O-glucopyranosyl trichloroacetimidates (12A, 12B). Copyright Taylor & Francis Group, LLC.