4258-37-1

Basic information

• Product Name: 2-methyl-1,3-diphenylprop-2-en-1-one
• CAS NO: 4258-37-1
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.2818
• Mol File: 4258-37-1.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 354.1°C at 760 mmHg
• Flash Point: 152.7°C
• Density: 1.078g/cm³
• Vapor Pressure: 3.44E-05mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 2-methyl-1,3-diphenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1,3-diphenylprop-2-en-1-one(4258-37-1)
• EPA Substance Registry System: 2-methyl-1,3-diphenylprop-2-en-1-one(4258-37-1)

Safety Data

• Hazardous Substances Data: 4258-37-1(Hazardous Substances Data)

Upstream product

• 21370-57-0 methyl 2-methyl-3-phenylacrylate 
• 198547-76-1 3-chloro-2-methyl-1,3-diphenyl-propan-1-one 
• 124-41-4 sodium methylate 
• 100-52-7 benzaldehyde 
• 93-55-0 1-phenyl-propan-1-one 
• 141-52-6 sodium ethanolate 
• 92593-15-2 selenophenyl α-methylcinnamate 
• 7647-01-0 hydrogenchloride 
• 6263-84-9 1,3,5-triphenyl-1,5-pentanedione 
• 108-88-3 toluene 
• 673-32-5 1-Phenylprop-1-yne 
• 774-48-1 (diethoxymethyl)benzene 
• 100-51-6 benzyl alcohol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 41231-80-5 (+/-)-3-hydroxy-2-methyl-1.3-diphenyl-butene-⁽¹⁾ 
• 74272-43-8 1-phenyl-2,3-dimethylindene 
• 857973-57-0 2-methyl-1,3-diphenyl-pentan-1-one 
• 1846-28-2 5-methyl-2,4,6-triphenylpyrimidine 
• 40685-26-5 2-methyl-1,3,3-triphenyl-propan-1-one 
• 14181-91-0 2,3-dibromo-2-methyl-1,3-diphenyl-propan-1-one 
• 31893-07-9 2-methyl-3-morpholin-4-yl-1,3-diphenyl-propan-1-one 
• 140846-03-3 3-Methyl-2,4-diphenyl-1,4-dihydro-benzo[4,5]imidazo[1,2-a]pyrimidine 
• 83909-23-3 4-Methyl-3,5-diphenyl-2-cyclohexen-1-on 
• 857181-43-2 triphenyl-1,3,5 methyl-4 pyrazoline 
• 4842-43-7 2-methyl-1,3-diphenylpropan-1-one 
• 158630-21-8 3,5-diphenyl-4-methyl-3,4-dihydro-2H-pyrrole-2,2-dicarboxylate de diethyle 
• 101168-81-4 α-Methyl-β-mercapto-β-phenyl-propiophenon 
• 861355-95-5 (2-methyl-3-oxo-1,3-diphenyl-propyl)-malonic acid dimethyl ester 

Relevant articles and documents

Palladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol

One-pot synthesis of α-methyl ketones starting from 1,3-diaryl propenols or 1-aryl propenols and methanol as a C1 source is demonstrated. This one-pot isomerization-methylation is catalyzed by commercially available Pd(OAc)2 with H2O as the only by-product. Mechanistic studies and deuterium labelling experiments indicate the involvement of isomerization of allyl alcohol followed by methylation through a hydrogen-borrowing pathway in these isomerization-methylation reactions.

Substituent-Controlled Divergent Cascade Cycloaddition Reactions of Chalcones and Arylalkynols: Access to Spiroketals and Oxa-Bridged Fused Heterocycles

Herein, we report substituent-controlled divergent cascade cycloaddition reactions of chalcones and arylalkynols in the presence of PtI2. Depending on the substituent on the chalcone, either spiroketals or oxa-bridged fused heterocycles could be obtained in the ranges of 86–97% and 87–95% yields under identical reaction conditions. Control experiments were carried out to elucidate the origin of the high chemoselectivity. These provide a method for the synthesis of a diverse array of structurally complex oxygen-containing heterocycles. (Figure presented.).

Photoredox β-thiol-α-carbonylation of enones accompanied by unexpected Csp2-C(CO) bond cleavage

An olefinic difunctionalization method of enones was presented hereviaaerobic visible-light catalysis. A novel reactivity was showcased in conjunction with the selective Csp2-C(CO) bond activation of enones, which provided a convenient method for the preparation of various β-thiolated-α-functionalized compounds. Moreover, the preliminary investigation of the mechanism indicated that a β-peroxysulfide intermediate was formed under the promotion of visible light under an oxygen atmosphere, which finally induced the unexpected C-C bond cleavage.