42596-46-3

Basic information

• Product Name: 2-HYDROXY-2-METHYLPROPANOHYDRAZIDE
• Synonyms: ART-CHEM-BB B015527;CHEMBRDG-BB 3015527;2-HYDROXY-2-METHYLPROPANOHYDRAZIDE;AKOS B015527;2-hydroxy-2-methylpropanohydrazide(SALTDATA: FREE);2-HYDROXY-2-METHYLPROPIONIC HYDRAZIDE;2-hydroxy-2-methylpropanehydrazide;2-hydroxy-2-methyl-propanehydrazide
• CAS NO: 42596-46-3
• Molecular Formula: C₄H₁₀N₂O₂
• Molecular Weight: 118.13
• Mol File: 42596-46-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 311°C at 760 mmHg
• Flash Point: 141.9°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 5.15E-05mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-HYDROXY-2-METHYLPROPANOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-2-METHYLPROPANOHYDRAZIDE(42596-46-3)
• EPA Substance Registry System: 2-HYDROXY-2-METHYLPROPANOHYDRAZIDE(42596-46-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 42596-46-3(Hazardous Substances Data)

Usage

Description

2-HYDROXY-2-METHYLPROPANOHYDRAZIDE, an organic compound with the chemical formula C4H10N2O2, is a hydrazide derivative of 2-hydroxy-2-methylpropanoic acid. It is recognized for its role in the synthesis of pharmaceuticals and other organic compounds, as well as its utility as a chelating agent and stabilizer in various chemical processes.

Uses

Used in Pharmaceutical Synthesis:
2-HYDROXY-2-METHYLPROPANOHYDRAZIDE is used as a reagent for the synthesis of pharmaceuticals and other organic compounds, contributing to the development of new drugs and therapeutic agents.
Used in Chelating Applications:
In the chemical industry, 2-HYDROXY-2-METHYLPROPANOHYDRAZIDE serves as a chelating agent, facilitating metal ion complex formation, which is crucial for various chemical reactions and processes.
Used as a Stabilizer in Organic Synthesis:
2-HYDROXY-2-METHYLPROPANOHYDRAZIDE is utilized as a stabilizer in organic synthesis, ensuring the stability of reactive intermediates and enhancing the overall efficiency of chemical reactions.
Used in Preparation of Carbohydrazide Derivatives:
2-HYDROXY-2-METHYLPROPANOHYDRAZIDE is employed in the preparation of carbohydrazide derivatives, which hold potential applications in pharmaceutical and medicinal chemistry, further expanding its utility in the development of novel therapeutic agents.

InChI:InChI=1/C4H10N2O2/c1-4(2,8)3(7)6-5/h8H,5H2,1-2H3,(H,6,7)

Upstream product

• 80-55-7 ethyl 2-hydroxy-2,2-dimethylethanoate 

Downstream Products

• 128153-87-7 2-Hydroxy-2-methyl-propionic acid [1-(2-chloro-4-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazide 
• 122433-05-0 2-Hydroxy-2-methyl-propionic acid [1-(2-chloro-phenyl)-prop-(E)-ylidene]-hydrazide 
• 133661-97-9 2-Hydroxy-2-methyl-propionic acid [1-(2-chloro-phenyl)-pent-(E)-ylidene]-hydrazide 
• 133662-06-3 2-Hydroxy-2-methyl-propionic acid [1-(2-chloro-phenyl)-2-hydroxy-eth-(Z)-ylidene]-hydrazide 
• 122432-89-7 2-Hydroxy-2-methyl-propionic acid [1-(2-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 42596-14-5 2-Hydroxy-2-methyl-propionic acid [1-(2,6-dichloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 128153-82-2 2-Hydroxy-2-methyl-propionic acid [1-(2,4-dichloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 128153-90-2 2-Hydroxy-2-methyl-propionic acid [1-(3,4-dichloro-phenyl)-eth-(E)-ylidene]-hydrazide 
• 122433-08-3 2-Hydroxy-2-methyl-propionic acid [1-(2-chloro-5-nitro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 860652-47-7 [8-chloro-6-(2,3-dimethoxyphenyl)-1-(1-hydroxy-1-methylethyl)-4H,6H-[1,2,4]triazolo[4,3-a][4,1]-benzoxazepin-4-yl]acetic acid ethyl ester 
• 1094044-05-9 2-[6-(4-{1,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]propan-2-ol 

Relevant articles and documents

Hydrazide Mimics for Protein Lysine Acylation to Assess Nucleosome Dynamics and Deubiquitinase Action

A range of acyl-lysine (acyl-Lys) modifications on histones and other proteins have been mapped over the past decade but for most, their functional and structural significance remains poorly characterized. One limitation in the study of acyl-Lys containing proteins is the challenge of producing them or their mimics in site-specifically modified forms. We describe a cysteine alkylation-based method to install hydrazide mimics of acyl-Lys post-translational modifications (PTMs) on proteins. We have applied this method to install mimics of acetyl-Lys, 2-hydroxyisobutyryl-Lys, and ubiquityl-Lys that could be recognized selectively by relevant acyl-Lys modification antibodies. The acyl-Lys modified histone H3 proteins were reconstituted into nucleosomes to study nucleosome dynamics and stability as a function of modification type and site. We also installed a ubiquityl-Lys mimic in histone H2B and generated a diubiquitin analog, both of which could be cleaved by deubiquitinating enzymes. Nucleosomes containing the H2B ubiquityl-Lys mimic were used to study the SAGA deubiquitinating module's molecular recognition. These results suggest that acyl-Lys mimics offer a relatively simple and promising strategy to study the role of acyl-Lys modifications in the function, structure, and regulation of proteins and protein complexes.

Antihypertensive actions of hydrazidones: Study of acylated dichloroarylhydrazones

A series of acylated dichloroarylhydrazones has been prepared and evaluated on spontaneously hypertensive rats (SHR). The presence of 2-Cl and 6-Cl aromatic substituents in a clonidine like position is not required since derivatives bearing 2- and 4-chloro as well as 3- and 4-chloro substituents exert antihypertensive activities. Activity is also maintained in certain 2,6 disubstituted derivatives where one of the chlorine atoms is replaced by F or NO2.