426842-70-8

Basic information

• Product Name: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester
• Synonyms: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester;1-Boc-4-allyl-4-piperidinecarboxylic Acid;1-[(tert-butoxy)carbonyl]-4-(prop-2-en-1-yl)piperidine-4-carboxylic acid;4-Allyl-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid;1-Boc-4-(2-propenyl)-4-piperidinecarboxylic acid;4-Allyl-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid
• CAS NO: 426842-70-8
• Molecular Formula: C₁₄H₂₃NO₄
• Molecular Weight: 269.34
• Product Categories: piperidine
• Mol File: 426842-70-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 380.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.101±0.06 g/cm3(Predicted)
• PKA: 4.55±0.20(Predicted)
• CAS DataBase Reference: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester(426842-70-8)
• EPA Substance Registry System: 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester(426842-70-8)

Safety Data

• Hazardous Substances Data: 426842-70-8(Hazardous Substances Data)

Usage

General Description

1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester is a chemical compound used in the production of pharmaceutical drugs. It is an ester derivative of piperidine carboxylic acid, and is commonly known as Memantine, which is used to treat moderate to severe Alzheimer's disease. 1,4-Piperidinedicarboxylic acid, 4-(2-propen-1-yl)-, 1-(1,1-dimethylethyl) ester works by blocking the receptor for the neurotransmitter glutamate in the brain, which helps to improve cognitive function and slow the progression of the disease. Additionally, it has also been studied for its potential neuroprotective and anti-inflammatory properties, making it a molecule of interest for further research in the field of neurodegenerative diseases.

Upstream product

• 441774-09-0 1-(tert-butyl) 4-methyl 4-allylpiperidine-1,4-dicarboxylate 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 146603-99-8 1-(1,1-dimethylethyl) 4-ethyl 4-(2-propenyl)-1,4-piperidinedicarboxylate 
• 676341-47-2 allyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 

Downstream Products

• 951745-39-4 (1,2-bis(4-methoxyphenyl)-2-oxoethyl) 1-tert-butoxycarbonyl-4-allyl-4-piperidinecarboxylate 
• 1192189-27-7 tert-butyl 4-allyl-4-(3-chlorophenylcarbamoyl)piperidine-1-carboxylate 
• 1192189-28-8 4-allyl-N-(3-chlorophenyl)piperidine-4-carboxamide hydrochloride 
• 1192189-26-6 4-allyl-N-(3-chlorophenyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 
• 1192190-10-5 3-[4-allyl-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate 
• 951743-90-1 4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-propyl-1-(N-hydroxy-N-methylcarbamoyl)piperidine 
• 951745-40-7 1-tert-butoxycarbonyl-4-allyl-4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)piperidine 
• 951743-89-8 4-allyl-4-(1,5-bis(4-methoxyphenyl)oxazol-2-yl)-1-(N-hydroxy-N-methylcarbamoyl)piperidine 

Relevant articles and documents

Iodoarene-Catalyzed Oxyamination of Unactivated Alkenes to Synthesize 5-Imino-2-Tetrahydrofuranyl Methanamine Derivatives

Reported here is the room-temperature metal-free iodoarene-catalyzed oxyamination of unactivated alkenes. In this process, the alkenes are difunctionalized by the oxygen atom of the amide group and the nitrogen in an exogenous HNTs2 molecule. This mild and open-air reaction provided an efficient synthesis to N-bistosyl-substituted 5-imino-2-tetrahydrofuranyl methanamine derivatives, which are important motifs in drug development and biological studies. Mechanistic study based on experiments and density functional theory calculations showed that this transformation proceeds via activation of the substrate alkene by an in situ generated cationic iodonium(III) intermediate, which is subsequently attacked by an oxygen atom (instead of nitrogen) of amides to form a five-membered ring intermediate. Finally, this intermediate undergoes an SN2 reaction by NTs2 as the nucleophile to give the oxygen and nitrogen difunctionalized 5-imino-2-tetrahydrofuranyl methanamine product. An asymmetric variant of the present alkene oxyamination using chiral iodoarenes as catalysts also gave promising results for some of the substrates.

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.

Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them

Heterocyclylalkylpiperidine derivatives of general formula (I) in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.