42710-26-9

Basic information

• Product Name: phenyl 2-bromopropanoate
• CAS NO: 42710-26-9
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.0706
• Mol File: 42710-26-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 270.5°C at 760 mmHg
• Flash Point: 117.4°C
• Density: 1.457g/cm³
• Vapor Pressure: 0.00682mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: phenyl 2-bromopropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 2-bromopropanoate(42710-26-9)
• EPA Substance Registry System: phenyl 2-bromopropanoate(42710-26-9)

Safety Data

• Hazardous Substances Data: 42710-26-9(Hazardous Substances Data)

Usage

General Description

Phenyl 2-bromopropanoate, also known as 2-bromo-1-phenylpropan-1-one, is an organic compound with the chemical formula C9H9BrO2. It is a colorless to pale yellow liquid with a fruity odor and is commonly used in the synthesis of pharmaceuticals and other organic chemicals. Phenyl 2-bromopropanoate is a versatile building block for the preparation of various compounds, and it is often used as a reagent in organic synthesis reactions. It is important to handle phenyl 2-bromopropanoate with care as it is considered to be a harmful and potentially hazardous chemical.

Upstream product

• 139-02-6 sodium phenoxide 
• 71-43-2 benzene 
• 563-76-8 α-bromopropionyl bromide 
• 108-95-2 phenol 
• 7148-74-5 2-Bromopropionyl chloride 
• 598-72-1 2-Bromopropionic acid 
• 164594-13-2 Phenyl[2-(trimethylsilyl)phenyl]iodonium trifluoromethanesulfonate 

Downstream Products

• 116435-79-1 2-phenoxy-propionic acid phenyl ester 
• 57927-12-5 2-methyl-benzofuran-3-ol 
• 53607-41-3 phenyl 2-nitropropanoate 
• 39489-70-8 2-(4-Chloro-phenoxy)-propionic acid phenyl ester 
• 52111-19-0 diethyl (1-carbamoylethyl)phosphonate 
• 126486-00-8 3-methyl-4,4-dipropyl-2-oxetanone 
• 74686-89-8 (+/-)-trans-4-tert-Butyl-3-methyloxetan-2-one 
• 126485-97-0 4,4-diethyl-3-methyl-2-oxetanone 
• 53946-87-5 2-bromo-(4'-hydroxyphenyl)-propan-1-one 
• 6968-35-0 7-hydroxy-indan-1-one 
• 3470-49-3 5-hydroxy-2,3-dihydro-1H-indene-1-one 
• 63923-67-1 2-bromo-1-(2-hydroxy-phenyl)-propan-1-one 

Relevant articles and documents

Cobalt-bisoxazoline-catalyzed asymmetric kumada cross-coupling of racemic α-bromo esters with aryl grignard reagents

The first cobalt-catalyzed asymmetric Kumada cross-coupling with high enantioselectivity has been developed. The reaction affords a unique strategy for the enantioselective arylation of α-bromo esters catalyzed by a cobalt-bisoxazoline complex. A variety of chiral α-arylalkanoic esters were prepared in excellent enantioselectivity and yield (up to 97% ee and 96% yield). The arylated products were transformed into α-arylcarboxylic acids and primary alcohols without erosion of ee. The new enantioenriched α-arylpropionic esters synthesized herein are potentially useful in the development of nonsteroidal anti-inflammatory drugs. This method was conducted on gram-scale and applied to the synthesis of highly enantioenriched (S)-fenoprofen and (S)-ar-turmerone.

O-arylation of carboxylic acids using (phenyl)[2-(trimethylsilyl)phenyl] iodonium triflate as a precursor of arynes

Using (phenyl)[2-(trimethylsilyl)phenyl]iodonium triflate as a precursor of arynes, Larock's method for O-arylation of carboxylic acids and arynes was developed. A variety of acids including simple aliphatic carboxylic acids, aromatic carboxylic acids, allenoic acids, and p-toluenesulfonic acid under mild reaction conditions could generate the aryl esters. Copyright Taylor & Francis Group, LLC.

Synthesis of substituted β-lactones by a Reformatsky reaction of carbonyl compounds, phenyl α-bromoalkanoates, and indium

Di-, tri-, and tetrasubstituted β-lactones are accessible in a one-step procedure by a Reformatsky reaction of phenyl α-bromoalkanoates with ketones or aldehydes at a sacrificial indium anode. With indium powder comparable results are obtained. The yield of β-lactones is significantly lower, if zinc is used instead of indium.