42746-49-6

Basic information

• Product Name: 5-benzyl-1,3-oxazolidin-2-one
• Synonyms: 5-Benzyloxazolidin-2-one;5-benzyl-1,3-oxazolidin-2-one;2-Oxazolidinone, 5-(phenylmethyl)-
• CAS NO: 42746-49-6
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.1998
• Mol File: 42746-49-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 108-109 °C
• Boiling Point: 398.8°C at 760 mmHg
• Flash Point: 195°C
• Density: 1.176g/cm³
• Vapor Pressure: 1.43E-06mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.78±0.40(Predicted)
• CAS DataBase Reference: 5-benzyl-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzyl-1,3-oxazolidin-2-one(42746-49-6)
• EPA Substance Registry System: 5-benzyl-1,3-oxazolidin-2-one(42746-49-6)

Safety Data

• Hazardous Substances Data: 42746-49-6(Hazardous Substances Data)

Upstream product

• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 51-79-6 urethane 
• 62825-83-6 3-benzoyl-5-benzyl-oxazolidin-2-one 
• 68395-97-1 2-hydroxy-3-phenylpropyl phenyl selenide 
• 598-55-0 methyl carbamate 
• 108-86-1 bromobenzene 
• 131118-90-6 (+/-)-benzyl (oxiran-2-ylmethyl)carbamate 
• 50411-26-2 3-phenyl-2-hydroxypropylamine 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 42746-50-9 5-benzyl-3-nitroso-oxazolidin-2-one 
• 62825-79-0 5-benzyl-3-methyl-oxazolidin-2-one 
• 62825-81-4 5-benzyl-3-propyl-oxazolidin-2-one 
• 62825-80-3 3-acetyl-5-benzyl-oxazolidin-2-one 
• 62825-84-7 5-benzyl-3-(2-dimethylamino-ethyl)-oxazolidin-2-one 
• 62825-83-6 3-benzoyl-5-benzyl-oxazolidin-2-one 
• 62825-82-5 (±)-N-benzyl-5-benzyloxazolidin-2-one 
• 62825-85-8 5-benzyl-3-(3-dimethylamino-propyl)-oxazolidin-2-one 

Relevant articles and documents

AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS

The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the treatment or prevention of various diseases, conditions or disorders.

GSK-3BETA INHIBITOR

For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.

Facile one-pot synthesis of oxazolidin-2-ones from phenyl 2-hydroxyalkyl selenides

A novel, convenient, efficient, three-step, one-pot synthesis of 2-oxazolidinones from phenyl 2-hydroxyalkyl selenides was developed. Using this methodology, 2-oxazolidinones are obtained in good yields (76-85%) by reaction of phenyl 2-hydroxyalkyl seleni