4277-43-4

Basic information

• Product Name: MAGNOFLORINE IODIDE, (+)-(RG)
• Synonyms: MAGNOFLORINE IODIDE, (+)-(RG);Nsc150447;Corytuberine Methiodide;(6aS)-5,6,6a,7-Tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-,4H-dibenzo[de,g]quinolinium iodide;Escholine iodide;Thalictrine iodide
• CAS NO: 4277-43-4
• Molecular Formula: C20H24NO4.I
• Molecular Weight: 469.313
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 4277-43-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 248-249℃
• Appearance: /
• CAS DataBase Reference: MAGNOFLORINE IODIDE, (+)-(RG)(CAS DataBase Reference)
• NIST Chemistry Reference: MAGNOFLORINE IODIDE, (+)-(RG)(4277-43-4)
• EPA Substance Registry System: MAGNOFLORINE IODIDE, (+)-(RG)(4277-43-4)

Safety Data

• Hazardous Substances Data: 4277-43-4(Hazardous Substances Data)

Usage

Description

Magnoflorine Iodide, (+)-(RG), is a minor alkaloid derived from the plant Stylophorum diphyllum. It possesses antimicrobial and antitumor properties, making it a potential candidate for various pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
Magnoflorine Iodide, (+)-(RG), is used as an antimicrobial agent for its ability to inhibit the growth of harmful microorganisms, which can be beneficial in the development of new antibiotics and antifungal medications.
Used in Anticancer Applications:
Magnoflorine Iodide, (+)-(RG), is used as an antitumor agent due to its potential to inhibit the growth and progression of cancer cells. It may be employed in the development of novel cancer treatments, particularly for solid malignancies.
Used in Drug Delivery Systems:
Magnoflorine Iodide, (+)-(RG), may also be utilized in the development of innovative drug delivery systems to enhance its bioavailability and therapeutic outcomes. This could involve the use of organic or metallic nanoparticles as carriers for improved delivery to target cells and tissues.

InChI:InChI=1/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1

Upstream product

• 6681-18-1 magnoflorine chloride 
• 517-56-6 corytuberine 
• 74-88-4 methyl iodide 

Downstream Products

• 5489-15-6 O,O'-Dimethyl-magnoflorin-iodid 

Relevant articles and documents

ALKALOIDS FROM Corydalis nobilis (L.) Pers. AND C. intermedia (L.) MERAT

Rhizomes of Corydalis nobilis (L.) Pers. (3percent of alkaloids) contain (+)-tetrahydropalmitine, (+)-bicuculline and (+)-corytuberine as the main constituents of the tertiary alkaloid fraction.Protopine, (+)-corypalmine and (+)-stylopine, which also belong to the dominant alkaloids, were isolated in lesser amounts.As minor alkaloids were isolated (+/-)-tetrahydropalmatine, (+)-corydaline, allocryptopine, cryptopine, (-)-scoulerine, (+)-adlumidine, (+)-sinactine, (+/-)-corlumine, isoboldine, (+)-corybulbine, (+/-)-stylopine and (-)-isocorypalmine.The fraction of quaternary protoberberine alkaloids afforded coptisine, dehydrocorydaline, palmatine, corysamine, jatrorrhyzine and cis-N-methylstylopinium hydroxide.Aobamidine (Z-adlumidiceine enol lactone), isolated as the principal alkaloid of aerial parts (0.3 percent of alkaloids), is obviously an artifact arising from bicuculline N-metho salt during the isolation process.Further dominant alkaloids of the tertiary fraction were adlumidine, bicuculline, protopine, (+/-)-tetrahydropalmatine and (+/-)-corlumine; as minor alkaloids were isolated corytuberine, scoulerine, corypalmine, cryptopine, isocorypalmine, corybulbine, (+)-corydalidzine, and unidentified alkaloids CN 1 (C23H25NO5, m.p.211 deg C) and CN 2 (m.p.261 deg C).Quternary protoberberine fraction afforded coptisine and palmatine.Nineteen of the mentioned alkaloids were isolated froom this species for the first time.Tubers of C.intermedia (L.) Merat (0.7 percent of alkaloids) afforded protopine, tetrahydropalmatine and corydaline as the main alkaloids and allocryptopine, canadine, stylopine, palmatine, dehydrocorydaline, berberine, coptisine as minor alkaloids, together with traces of bicuculline and magnoflorine.Dominant alkaloids of the aerial part (0.73 percent of alkaloids) were bicuculline, bulbocapnine, protopine, stilopine and an unidentified phenolic base, m.p. 258 deg C.Isoboldine, scoulerine, allocryptopine, corydaline, canadine, coptisine, palmatine and berberine were identified as the minor alkaloids.

Alkaloids from Tinospora cordifolia Miers

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