427885-96-9

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 3-[methyl[(2-nitrophenyl)sulfonyl]amino]-, 1,1-dimethylethyl ester, (3S)-
• CAS NO: 427885-96-9
• Molecular Formula: C16H23N3O6S
• Molecular Weight: 385.441
• Mol File: 427885-96-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 3-[methyl[(2-nitrophenyl)sulfonyl]amino]-, 1,1-dimethylethyl ester, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 3-[methyl[(2-nitrophenyl)sulfonyl]amino]-, 1,1-dimethylethyl ester, (3S)-(427885-96-9)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 3-[methyl[(2-nitrophenyl)sulfonyl]amino]-, 1,1-dimethylethyl ester, (3S)-(427885-96-9)

Safety Data

• Hazardous Substances Data: 427885-96-9(Hazardous Substances Data)

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 427885-95-8 tert-butyl (3S)-3-[(2-nitrophenyl)sulfonylamino]pyrrolidine-1-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 147081-59-2 tert-butyl (3S)-3-(methylamino)pyrrolidine-1-carboxylate 
• 427885-97-0 (S)-N-methyl-2-nitro-N-(pyrrolidin-3-yl)benzenesulfonamide 

Relevant articles and documents

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity

We synthesized derivatives of a natural alkaloid, conolidine, and evaluated these derivatives in the acetic acid-induced writhing test and formalin test in ddY mice after oral administration. As a result, we identified (5S)-6-methyl-1,3,4,5,6,8-hexahydro-7H-2,5-methano[1,5]diazonino[7,8-b]indol-7-one sulfate salt, 15a (DS54360155), with a unique and original bicyclic skeleton, as an analgesic more potent than conolidine. Moreover, 15a did not exhibit mu-opioid receptor agonist activity.