4279-76-9 Usage
Description
(Ethynyloxy)benzene, also known as phenyl ethynyl ether, is a chemical compound with the formula C8H6O. It is a colorless liquid with a distinct odor and is typically used as a reagent in organic synthesis. (ethynyloxy)benzene is a highly flammable and potentially hazardous substance, which necessitates careful handling and adherence to proper safety protocols.
Uses
Used in Pharmaceutical Industry:
(Ethynyloxy)benzene is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of medicinal agents, contributing to the development of new drugs and therapies.
Used in Dye Industry:
In the dye industry, (ethynyloxy)benzene serves as a crucial component in the production of different types of dyes. Its chemical properties enable the creation of vibrant and stable colorants used in various applications, such as textiles, plastics, and printing inks.
Used in Fragrance Industry:
(Ethynyloxy)benzene is also utilized as a starting material in the fragrance industry. Its distinct odor and reactivity make it a valuable component in the formulation of various scent compounds, enhancing the sensory experience of consumer products.
Used as a Coupling Agent in Organic Synthesis:
Due to its reactivity, (ethynyloxy)benzene is employed as a coupling agent in the synthesis of organic compounds. It facilitates the formation of new chemical bonds, enabling the creation of complex molecular structures with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 4279-76-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,7 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4279-76:
(6*4)+(5*2)+(4*7)+(3*9)+(2*7)+(1*6)=109
109 % 10 = 9
So 4279-76-9 is a valid CAS Registry Number.
4279-76-9Relevant articles and documents
Enantioselective Heck Arylation of Acyclic Alkenol Aryl Ethers: Synthetic Applications and DFT Investigation of the Stereoselectivity
Polo, Ellen Christine,Wang, Martí Fernández,Angnes, Ricardo Almir,Braga, Ataualpa A. C.,Correia, Carlos Roque Duarte
, p. 884 - 892 (2019/12/30)
Herein we report the enantioselective Heck-Matsuda arylation of acyclic E and Z-alkenyl aryl ethers. The reactions were carried out under mild conditions affording the enantioenriched benzyl ethers in a regioselective manner, moderate to good yields (up to 73%), and in good to excellent enantiomeric ratios (up to 97:3). The enantioselective Heck-Matsuda arylation has shown a broad scope (25 examples), and some key Heck-Matsuda adducts were further converted into more complex and valuable scaffolds including their synthetic application in the synthesis of (R)-Fluoxetine, (R)-Atomoxetine, and in the synthesis of an enantioenriched benzo[c]chromene. Finally, in silico mechanistic investigations into the reaction's enantioselectivity were performed using density functional theory. (Figure presented.).
Metal-free oxidative cyclization of alkynyl aryl ethers to benzofuranones
Graf, Katharina,Ruehl, Carmen L.,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.
, p. 12727 - 12731 (2013/12/04)
Readily available phenols can be converted into substituted aryl alkynyl ethers, which react with an N-oxide as an oxidant and catalytic amounts of a Bronsted acid to provide benzofuranones. If non-terminal alkynyl ethers are applied, a 1,2-hydride shift takes place and phenyl acrylates are obtained. Thus activated alkynes can serve as α-oxy carbene precursors even in the absence of a metal catalyst. Copyright
