4280-30-2

Basic information

• Product Name: 1-(4-CHLORO-PHENYL)-PYRROLIDINE
• Synonyms: 1-(4-CHLORO-PHENYL)-PYRROLIDINE;Pyrrolidine, 1-(4-chlorophenyl)-
• CAS NO: 4280-30-2
• Molecular Formula: C₁₀H₁₂ClN
• Molecular Weight: 181.66198
• Mol File: 4280-30-2.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 288.4°Cat760mmHg
• Flash Point: 128.2°C
• Appearance: /
• Density: 1.165g/cm³
• Vapor Pressure: 0.00235mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 1-(4-CHLORO-PHENYL)-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLORO-PHENYL)-PYRROLIDINE(4280-30-2)
• EPA Substance Registry System: 1-(4-CHLORO-PHENYL)-PYRROLIDINE(4280-30-2)

Safety Data

• Hazardous Substances Data: 4280-30-2(Hazardous Substances Data)

Usage

General Description

1-(4-chloro-phenyl)-pyrrolidine, also known as 4-chloropyrrolidine, is a chemical compound with a molecular formula of C9H12ClN. It is a white solid that is soluble in organic solvents and is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. 4-chloropyrrolidine has been identified as a potential intermediate in the manufacture of drugs such as varenicline, an FDA-approved medication for smoking cessation. The compound has also been studied for its potential use in the treatment of various neurological and psychiatric disorders, due to its ability to interact with certain receptors in the brain. However, as with all chemical compounds, proper safety precautions and handling procedures should be followed when working with 1-(4-chloro-phenyl)-pyrrolidine to prevent accidents and exposure.

InChI:InChI=1/C10H12ClN/c11-9-3-5-10(6-4-9)12-7-1-2-8-12/h3-6H,1-2,7-8H2

Upstream product

• 106-47-8 4-chloro-aniline 
• 110-56-5 1,4-dichlorobutane 
• 6943-00-6 1-(4-chlorophenyl)pyrrolidine-2,5-dione 
• 110-52-1 1,4-dibromo-butane 
• 110-63-4 Butane-1,4-diol 
• 638-37-9 butanedial 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 698-69-1 4-chloro-N,N-dimethylaniline 
• 123-75-1 pyrrolidine 
• 29540-84-9 4-chlorophenyl trifluoromethanesulfonate 
• 106-39-8 bromochlorobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 55-98-1 busulfan 
• 109-99-9 tetrahydrofuran 

Downstream Products

• 41173-36-8 5-chloro-2-(1-pyrrolidinyl)nitrobenzene 
• 58973-25-4 C₁₀H₁₀ClNS 

Relevant articles and documents

GAS-PHASE BASICITY AND IONIZATION ENERGIES IN SOME N-ARYLAZACYCLOALKANES

Proton-transfer equilibrium constant and ionization energy measurement were performed in the gas phase for a series of N-arylazacycloalkanes.The techniques used were Fourier transform ion cyclotron resonance (FT-ICR) and UV photoelectron spectroscopy (UPS

I2/NaH2PO2-mediated deoxyamination of cyclic ethers for the synthesis of: N -aryl-substituted azacycles

We have developed a protocol for efficient synthesis of N-aryl-substituted azacycles from aryl amines and cyclic ethers using I2/NaH2PO2 as the mediator. A diverse range of aryl amines and cyclic ethers undergo amination reaction to generate products in good to excellent yields with good functional group tolerance. This reaction can be easily scaled up to give N-aryl-substituted azacycles on a gram scale. Further chemical manipulation of the products enabled useful transformations of the quinoline ring, including bromination and acetylation. This journal is

Organic photoredox catalytic α-C(sp3)-H phosphorylation of saturated: Aza -heterocycles

A metal-free C(sp3)-H phosphorylation of saturated aza-heterocycles via the merger of organic photoredox and Br?nsted acid catalyses was established under mild conditions. This protocol provided straightforward and economic access to a variety of valuable α-phosphoryl cyclic amines by using commercially available diarylphosphine oxide reagents. In addition, the D-A fluorescent molecule DCQ was used for the first time as a photocatalyst and exhibited an excellent photoredox catalytic efficiency in this transformation. A series of mechanistic experiments and DFT calculations demonstrated that this transformation underwent a sequential visible light photoredox catalytic oxidation/nucleophilic addition process.