42833-66-9 Usage
Description
2,4,5-TRIMETHOXY-BENZOYL CHLORIDE is an organic compound with the chemical formula C10H9ClO4. It is a derivative of benzoic acid, featuring three methoxy groups at the 2nd, 4th, and 5th positions, and a chlorine atom attached to the benzoyl group. 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE is typically used as an intermediate in the synthesis of various pharmaceuticals and organic compounds due to its reactive nature and functional groups.
Uses
Used in Pharmaceutical Synthesis:
2,4,5-TRIMETHOXY-BENZOYL CHLORIDE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its reactive benzoyl chloride group allows for the formation of amide and ester linkages, which are crucial in the development of new drugs.
Used in the Synthesis of Acotiamide (A190260):
2,4,5-TRIMETHOXY-BENZOYL CHLORIDE is used as an intermediate for the synthesis of 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic Acid (H972788), which is an impurity of Acotiamide (A190260). Acotiamide is an acetylcholinesterase inhibitor that has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats.
Used in the Treatment of Functional Dyspepsia:
Acotiamide Hydrochloride, synthesized using 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE, has been shown to improve meal-related symptoms of functional dyspepsia, a common gastrointestinal disorder characterized by chronic discomfort or pain in the upper abdomen.
Check Digit Verification of cas no
The CAS Registry Mumber 42833-66-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,8,3 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 42833-66:
(7*4)+(6*2)+(5*8)+(4*3)+(3*3)+(2*6)+(1*6)=119
119 % 10 = 9
So 42833-66-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H11ClO4/c1-13-7-5-9(15-3)8(14-2)4-6(7)10(11)12/h4-5H,1-3H3
42833-66-9Relevant articles and documents
Synthesis and in silico and in vitro evaluation of trimethoxy-benzamides designed as anti-prion derivatives
Concei??o, Raissa A.,Ascari, Lucas M.,Ferreira, Natália C.,Goes, Carolina F.,Matos, Carolina O.,Pinheiro, Anderson S.,Alves, Marina A.,Souza, Alessandra M. T.,Maia, Rodolfo C.,Caughey, Byron,Cordeiro, Yraima,Barbosa, Maria Letícia C.
, p. 2128 - 2141 (2019)
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are neurodegenerative disorders which affect mammals, including the human species, and arise after the conversion of the monomeric cellular prion protein (PrPC) int
Preparation method of acotiamide hydrochloride impurity
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Paragraph 0020-00021, (2020/08/30)
The invention discloses a preparation method of an acotiamide hydrochloride impurity, which comprises the following steps: carrying out acylating chlorination on raw material 2, 4, 5-trimethoxybenzoicacid to obtain 2, 4, 5-trimethoxybenzoyl chloride, and
Method for synthesizing acotiamide hydrochloride
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Paragraph 0007; 0017; 0018; 0019, (2018/09/08)
The invention discloses a method for synthesizing acotiamide hydrochloride. According to the method, 2,4,5-trimethoxybenzoic acid, thionyl chloride, methylbenzene, dichloromethane, 2-aminothiazole-4-ethyl formate, N-N-dimethyl formamide, pyridine Hydrochl
