4284-49-5

Basic information

• Product Name: N-(4-methoxyphenyl)ethanesulfonamide
• Synonyms: N-(4-methoxyphenyl)ethanesulfonamide
• CAS NO: 4284-49-5
• Molecular Formula: C₉H₁₃NO₃S
• Molecular Weight: 215.26942
• Mol File: 4284-49-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-methoxyphenyl)ethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)ethanesulfonamide(4284-49-5)
• EPA Substance Registry System: N-(4-methoxyphenyl)ethanesulfonamide(4284-49-5)

Safety Data

• Hazardous Substances Data: 4284-49-5(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 594-44-5 Ethanesulfonyl chloride 

Downstream Products

• 93117-02-3 ethanesulfonic acid-(2,5-dichloro-4-methoxy-anilide) 
• 99987-00-5 N-acetyl-N-ethanesulfonyl-p-anisidine 
• 4284-64-4 2-Ethanesulfonyl-4-methoxy-phenylamine 
• 22856-83-3 N-allyl-N-(4-methoxy-phenyl)-ethanesulfonamide 

Relevant articles and documents

Ultrasound-assisted one-pot three-component synthesis of new isoxazolines bearing sulfonamides and their evaluation against hematological malignancies

In the present study, following a one-pot two-step protocol, we have synthesized novel sulfonamides-isoxazolines hybrids (3a-r) via a highly regioselective 1,3-dipolar cycloaddition. The present methodology capitalized on trichloroisocyanuric acid (TCCA) as a safe and ecological oxidant and chlorinating agent for the in-situ conversion of aldehydes to nitrile oxides in the presence of hydroxylamine hydrochloride, under ultrasound activation. These nitrile oxides could be engaged in 1,3-dipolar cycloaddition reactions with various alkene to afford the targeted sulfonamides-isoxazolines hybrids (3a-r). The latter were assessed for their antineoplastic activity against model leukemia cell lines (Chronic Myeloid Leukemia, K562 and Promyelocytic Leukemia, HL-60).